Publications by authors named "Mahsa Ziasistani"
Pulmonary arterial hypertension (PAH) is a severe disease that leads to pulmonary vascular remodeling characterized by a rise in pulmonary vascular resistance and pressure. We assessed the effects of an herbal compound, berberine (BB), and some related mechanisms on PAH in rats. Male Wistar rats were assigned to seven groups: control, monocrotaline (MCT), MCT+vehicle, and MCT+BB (with doses of 10, 20, 30, and 40 mg/kg) groups.
View Article and Find Full Text PDFHerein, we designed a DNA framework-based intelligent nanorobot using toehold-mediated strand displacement reaction-based molecular programming and logic gate operation for the selective and synchronous detection of miR21 and miR125b, which are known as significant cancer biomarkers. Moreover, to investigate the applicability of our design, DNA nanorobots were implemented as capping agents onto the pores of MSNs. These agents can develop a logic-responsive hybrid nanostructure capable of specific drug release in the presence of both targets.
View Article and Find Full Text PDFCancer stem cells (CSCs), a subgroup of cancer cells, have self-renewal capacity and differentiation potential and drive tumor growth. CSCs are highly-resistant to conventional chemo-radio therapy. Phytochemicals were shown to be able to eliminate CSCs.
View Article and Find Full Text PDFMain Purpose: This study aimed to determine any association of KRAS and BRAF mutations in colorectal cancer with clinicopathological features and overall survival (OS) of Southeast Iranian colorectal cancer (CRC) patients.
Methods: Overall, KRAS and BRAF status were assessed in 100 Iranian CRC subjects. A hundred consecutive stages I-IV CRC patients, who underwent surgical tumor resection from February 2012 to August 2015, were prospectively attained from three centers and were enrolled in the research.
Aim: The aim of this study was the genetic characterization of two clinical vancomycin-resistant (VRSA) isolates.
Materials And Methods: Resistance to vancomycin was determined by phenotypic method. PCR was used for detection of (2")-Ic, (3')-IIIa, , Immune Evasion Cluster [ and ] genes and biofilm operon ABCD.
Introduction: The emergence and spread of strains resistant to multiple antimicrobial agents are considered as a serious challenge for nosocomial infections.
Materials And Methods: In this study, 175 nonrepetitive clinical isolates of were collected from hospitalized patients in Kerman, Iran. Extended-spectrum β-lactamases (ESBLs), AmpC, and carbapenemase-producing isolates were recognized by phenotypic methods.
Background And Objectives: is the main Gram-positive bacteria isolated from patients with ocular infections. Herein, we describe the pattern of antibiotic resistance, presence of resistance genes including and the cytotoxin gene in isolates collected from patients with external ocular infection.
Materials And Methods: In this study, 8 isolates were collected from 81 patients that suffered from eye damage.
Objective: Design and validation of Real-time PCR on the protected gene region ITS2 to quantify the parasite load in common leishmania (L) species.
Materials And Methods: Probe and primer were designed from the ITS2 region between the rRNA genes with minimum gene variation in three common leishmania species followed by a Real-time PCR using the Taq man probe method in the form of absolute quantification. A series of different concentrations of leishmania were analyzed.