Automated and semi-automated packed sorbent solid phase (micro) extraction methods for extraction of organic and inorganic pollutants.

In this study, the packed sorbent solid phase (micro) extraction methods from manual to automated modes are reviewed. The automatic methods have several remarkable advantages such as high sample throughput, reproducibility, sensitivity, and extraction efficiency. These methods include solid-phase extraction, pipette tip micro-solid phase extraction, microextraction by packed sorbent, in-tip solid phase microextraction, in-tube solid phase microextraction, lab-on-a-chip, and lab-on-a-valve.

Microextraction by packed sorbent of some β-blocker drugs with chitosan@mof-199 bio-composite in human saliva, plasma, and urine samples.

The current study introduces microextraction by packed sorbent (MEPS) to extract three beta-blocker drugs (propranolol, atenolol, and betaxolol) from biological samples. The separation and detection of the drugs were performed by high performance liquid chromatography followed by UV detection. A green approach was applied for synthesizing chitosan@MOF-199 bio-composite, which was packed into the initial part of a metal spinal (22 gage).