Tumor-derived exosomes: Potential biomarkers and therapeutic target in the treatment of colorectal cancer.

Colorectal cancer (CRC) is the third most common cause of cancer-related death in men and women in many countries. Early detection of CRC helps to prevent the advanced stages of the disease, and may thereby improve the survival of these patients. A noninvasive test with high specificity and sensitivity is required for this.

A genetic variant in the cytochrome P450 family 2 subfamily R member 1 determines response to vitamin D supplementation.

Background: Globally, about 1 billion people have inadequate levels of serum vitamin D and it is prevalent in all ethnicities and age groups. Few foods naturally contain sufficient vitamin D; therefore, most people get their requirements through supplementation. Hence vitamin D status is affected by genetic and environmental determinants including season of measurement, diet habitual, health status, body mass index and concurrent medication.

Interaction between a variant of CDKN2A/B-gene with lifestyle factors in determining dyslipidemia and estimated cardiovascular risk: A step toward personalized nutrition.

Background & Aims: Several genome-wide-association-studies have identified genetic variants in a region on chromosome 9p21 that are associated with an increased risk of Cardiovascular disease (CVD) and diabetes. Here we have explored the interaction of a genetic variant of the CDKN2A/B-rs10811661 gene locus with cardiovascular risk factors and environmental-exposures (e.g.

Metabolic syndrome components as markers to prognosticate the risk of developing chronic kidney disease: evidence-based study with 6492 individuals.

Objective: The global prevalence of metabolic syndrome (MetS) appears to be increasing and the impact of this condition on potential comorbidities such as cardiovascular disease is high. Chronic kidney disease (CKD) is also a potential comorbidity of MetS but the method of screening for this is somewhat controversial. Thus, predictive markers that can predict the risk of developing CKD are warranted for identification of patients with MetS at an increased risk.