Investigating the Relationship between FGF2 Gene Expression and Airway Remodeling in Severe Asthma.

Severe asthma causes chronic airway inflammation and structural changes in the bronchial wall. Fibroblast growth factor 2 (FGF2) plays an inflammatory role in specific pathways in airway remodeling in asthma. Assessing the relationship between sputum pattern, bronchial thickness by high-resolution computed tomography (HRCT) scan, and FGF2 expression level can evaluate the role of FGF2 in asthma remodeling.

Comparison of the effects of itraconazole and prednisolone on -2 gene expression and clinical manifestations in patients with persistent severe asthma.

Background And Purpose: Considering the possible role of fungal sensitization in the treatment of resistant asthma, which may lead to the remodeling of bronchial structure, we theorized that itraconazole could result in better control of asthma. In this regard, this study aimed to compare the effects of itraconazole and prednisolone (routinely prescribed) on clinical, structural, and biomarker findings of the remodeling of asthma.

Materials And Methods: This double-blind controlled randomized clinical trial was performed on 70 adult patients suffering from severe persistent asthma.

Effective Treatment of Chronic Cough with Tinidazole as the Newest Antiprotozoa against .

Background: Chronic cough is a common problem in the setting of family physicians. Recently, was considered a cause of respiratory symptoms in children and adults.

Objective: This study is aimed at determining the effect of antiprotozoal treatment of in patients with a chronic cough in Mashhad during 2020-2021.