Publications by authors named "Mahsa Asadniaye Fardjahromi"

Microfluidic devices have shown promising applications in the bioprocessing industry. However, the lack of modularity and high cost of testing and error limit their implementation in the industry. Advances in 3D printing technologies have facilitated the conversion of microfluidic devices from research output to applicable industrial systems.

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Biphasic calcium phosphate ceramics (BCPs) have been extensively used as a bone graft in dental clinics to reconstruct lost bone in the jaw and peri-implant hard tissue due to their good bone conduction and similar chemical structure to the teeth and bone. However, BCPs are not inherently osteoinductive and need additional modification and treatment to enhance their osteoinductivity. The present study aims to develop an innovative strategy to improve the osteoinductivity of BCPs using unique features of zeolitic imidazolate framework-8 (ZIF8).

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Article Synopsis
  • Metal-organic frameworks (MOFs), specifically zeolitic imidazolate framework-8 (ZIF8), are explored for creating a new composite microcarrier (MC) to support human mesenchymal stem cells (hMSCs) adhesion and growth due to their high porosity and tunable features.
  • The ZIF8 MCs were developed by combining polydopamine and polyethyleneimine on polystyrene beads, and various techniques were used to analyze their chemical properties and stability.
  • Tests showed that ZIF8 MCs provided an excellent environment for human adipose-derived mesenchymal stem cells (hADSCs) to adhere and grow, indicating their potential as cost-effective tools for promoting cell culture in tissue engineering
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