Publications by authors named "Mahon H"

Article Synopsis
  • Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare disorder that is difficult to diagnose due to diverse symptoms and a lack of awareness, often resulting in misdiagnosis.
  • This study explores the use of a machine learning model, specifically the XGBoost algorithm, to identify undiagnosed PNH patients using electronic health records from the UK, involving 131 PNH patients and over 593,000 controls.
  • The model achieved a recall rate of 27% for PNH patients, with a specificity of 99.99% for controls, and indicated that nearly 1 in 5 flagged patients may need further investigation for PNH, highlighting key symptoms like aplastic anemia and panc
View Article and Find Full Text PDF
Article Synopsis
  • * Researchers analyzed data from the Optimum Patient Care Research Database, utilizing various modeling approaches, including logistic regression and XGBoost, to develop clinical prediction models.
  • * The XGBoost model showed promising accuracy in identifying undiagnosed small intestine NETs, suggesting that these models could aid in earlier identification, though further evaluation is needed to assess their effectiveness and cost-efficiency.
View Article and Find Full Text PDF

Context: X-linked hypophosphatemia (XLH) is a rare genetic disorder causing renal phosphate wasting, which predicates musculoskeletal manifestations such as rickets. Diagnosis is often delayed.

Objective: To explore the recording of clinical features, and the diagnostic odyssey of children and adolescents with XLH in primary care electronic healthcare records (EHRs) in the United Kingdom.

View Article and Find Full Text PDF

Introduction: Hip fractures often occur in medically complex patients and can be associated with high perioperative mortality. Mortality risk assessment tools that are specific to hip fracture patients have not been extensively studied. The objective of this study is to evaluate a recently published 30-day mortality risk calculator (Hip Fracture Estimator of Mortality Amsterdam [HEMA]) in a group of patients treated at a university health system.

View Article and Find Full Text PDF
Article Synopsis
  • This study assessed the implementation of MendelScan, a tool designed to find rare diseases in a UK primary care setting, addressing challenges like complexity and low physician awareness in diagnosing these conditions.
  • The process involved analyzing data from 68,705 patients, using algorithms to flag potential cases based on medical records, leading to a clinical review of flagged patients to identify those needing further investigation.
  • Out of the flagged cases, 75 records passed the review, resulting in 36 reports sent to GPs, with some categorized as possible diagnoses and others excluded due to existing clear diagnoses.
View Article and Find Full Text PDF

Identifying the structures of the lateral knee is critical during knee posterolateral corner reconstruction. Several methods exist that can help estimate the femoral insertions of these structures on lateral radiographs. However, it is important to recognize the limitations of these methods and that anatomic visualization is often more practical and more accurate.

View Article and Find Full Text PDF

Biological control offers a long-term and sustainable option for controlling the destructive forest pest emerald ash borer (EAB), Agrilus planipennis Fairmaire, in North America. Three larval parasitoids, Spathius agrili Yang (Hymenoptera: Braconidae), Tetrastichus planipennisi Yang (Eulophidae), and Spathius galinae Belokobylskij & Strazanac, have been introduced to North America from the native range of EAB (northeastern Asia). While T.

View Article and Find Full Text PDF

The manifestation of glenohumeral arthritis in the young adult is a devastating occurrence that can be difficult to manage. This review details the many underlying etiologies including genetic causes, congenital abnormalities, glenohumeral instability, posttraumatic lesions, postcapsulorraphy arthropathy, osteonecrosis, intraarticular pain pump postoperative use, radiofrequency/thermal capsulorraphy treatments, septic arthritis/infection, and inflammatory arthropathies. Although each of these potential causes have been well-studied, their contributions to the development of glenohumeral arthritis in the young person has not been described extensively.

View Article and Find Full Text PDF

Rotator cuff repair is an increasingly common orthopedic procedure. As with any surgical procedure, the complications can be potentially devastating when they do happen to occur. This review attempts to summarize the most frequently encountered complications, including retear, failure to heal, stiffness, missed concomitant pathology, and infection.

View Article and Find Full Text PDF

Background: To determine patient-related risk factors for infection following knee arthroscopy using two large databases.

Methods: A private-payer (PP) and Medicare national insurance database were queried for patients undergoing simple knee arthroscopy procedures from 2005 to 2015. Patients undergoing concomitant open or complex procedures with grafts were excluded.

View Article and Find Full Text PDF

Maintenance of cardiac function is critical to the survival of patients with end-stage liver disease after liver transplantation (LT). We sought to determine whether pre-LT echocardiographic indices of right heart structure and function were independently predictive of morbidity and mortality post-LT. We retrospectively studied 216 consecutive patients who underwent pre-LT 2-dimensional/Doppler echocardiography with subsequent LT from 2007 to 2010.

View Article and Find Full Text PDF

Background: The Canadian Best Practice Recommendations for Stroke Care suggest that (1) all patients with stroke should be screened for cognitive impairment and (2) persons who are detected as having cognitive impairment on a screening test should receive additional cognitive assessment. The purpose of this study is to determine whether care in an Ontario inpatient stroke rehabilitation facility is consistent with these recommendations.

Methods: Stroke patients discharged from an inpatient stroke rehabilitation program located in Southwestern Ontario, Canada, from May to October 2009 were included in this study.

View Article and Find Full Text PDF

Background And Purpose: Although Canadian best practice recommendations regarding assessment and management of poststroke depression (PSD) have been established, the degree to which these evidence-based guidelines have been translated into practice is not known. The objectives of the present study are to compare current and recommended best practice and examine possible reasons for identified care gaps.

Methods: Practice audit by chart review was performed to identify recorded screening, assessment, and treatment for PSD in patients discharged from a specialized inpatient rehabilitation program over a 6-month period.

View Article and Find Full Text PDF