Emotional behaviors as well as the hippocampal reelin expression in C57BL/6N male mice chronically treated with corticosterone.

Depression is a common psychiatric disorder affecting around 300 million people worldwide. Serum cortisol and glucocorticoid levels in humans are reportedly higher in patients with depression compared to controls. Furthermore, rodents repeatedly treated with exogenous corticosterone (CORT), a glucocorticoid in rodents, exhibit deficits in emotional behaviors.

New surgical scoring system to predict postoperative mortality.

Purpose: There is still no easy and highly useful method to comprehensively assess both preoperative and intraoperative patient statuses to predict postoperative outcomes. We attempted to develop a new scoring system that would enable a comprehensive assessment of preoperative and intraoperative patient statuses instantly at the end of anesthesia, predicting postoperative mortality.

Methods: The study included 32,555 patients who underwent surgery under general or regional anesthesia from 2008 to 2012.

[Case of respiratory arrest during intraoperative magnetic resonance imaging (iMRI) for awake craniotomy].

We had a neurosurgical patient who developed apnea during iMRI. She was suspected of obstructive sleep apnea. The tumor had a risk of motor aphasia, and therefore awake craniotomy with iMRI was planned.

Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands.

Sigma1 receptors (Sigma1R) are intracellular chaperone proteins that bind psychotropic drugs and also clinically used drugs such as ketamine and haloperidol. Co-expression of the Sigma1R has been reported to enhance the sensitivity of several voltage-gated ion channels to Sigma1R ligands. Kv1.

[Can preoperative administration of H2 blocker reduce the incidence of postoperative nausea and vomiting (PONV)?].

Background: PONV is a complication that reduces a patient's quality of life (QOL). Recently, it was reported that PONV is reduced by preoperative administration of histamine receptor (H1 and H2) inhibitor. In the present study, based on the hypothesis that PONV might be reduced by preoperative administration of H2 blocker, we examined the effect of preoperative administration of H2 blocker only on the incidence of PONV.

[Urine specific gravity during general anesthesia].

Background: The urine volume and urine specific gravity per unit time during a short operation under volume loading were examined to explore the possibility of urine specific gravity as an indirect index of fluid therapy.

Methods: After introducing anesthesia, under volume loading with acetic acid Ringer solution 10 ml x kg(-1) x hr(-1), urine volume and specific gravity per unit time at 30 min intervals from urination to 90 min later and the correlation between the urine volume and urine specific gravity were examined. A chronological increase of urine specific gravity was also confirmed.

[The injection pain of propofol with different emulsion].

Background: Incidence and intensity of pain on intravenous injection of propofol were assessed with emulsion of long-chain/medium-chain triglycerides (LCT/MCT, 50: 50) and only long-chain triglycerides (LCT, 100) in patients undergoing different elective surgical interventions in this prospective, randomized, cross over and double-blinded study.

Methods: 1) Forty six patients were assigned to two groups. One group received 0.