Publications by authors named "Maho Jingu"
Article Synopsis
- Normal cells regulate growth and maturation through precise gene expression changes influenced by the epigenome, but the epigenetic shifts during cancer progression are not well-understood.
- This study focuses on medulloblastoma, an embryonal brain tumor, and reveals key epigenomic changes that differentiate precancerous cells from malignant ones.
- It identifies the nuclear factor I (NFIB) transcription factor as a significant player in cancer development, showing that inhibiting NFIB can disrupt the cancer-specific epigenome, highlighting the role of non-mutational mechanisms in tumorigenesis.
Adhesion of cancer cells to vascular endothelial cells in target organs is an initial step in cancer metastasis. Our previous studies revealed that amphoterin-induced gene and open reading frame 2 (AMIGO2) promotes the adhesion of tumor cells to liver endothelial cells, followed by the formation of liver metastasis in a mouse model. However, the precise mechanism underlying AMIGO2-promoted the adhesion of tumor cells and liver endothelial cells remains unknown.
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