Temporal variations in COVID-19: an epidemiological discussion with a practical application.

Objective: We aimed to characterize the temporal variation in coronavirus disease 2019 (COVID-19) infection and mortality as a possible tool to monitor and control the spread of this disease.

Methods: We analyzed cyclicity and synchronicity in cases of COVID-19 infection and time series of deaths using Fourier transform, its inverse method, and statistical treatments. Epidemiological indices (e.

Possible effect of epinephrine in minimizing COVID-19 severity: a review.

Objective: Coronavirus disease 2019 (COVID-19) shows a wide range of severity, ranging from an asymptomatic presentation to a severe illness requiring intensive care unit admission. Identification of a strategy to manage the severity of this disease will not only help to reduce its case fatality but also help to remove some of the burden from the already overwhelmed health care systems. While successful management of symptoms in general is important, identifying measures to modify the severity of the illness is a key factor in the fight against this pandemic.

The impact of supramolecular chemistry in medicine: removing the border between infectious and non-infectious diseases.

The concept, molecular self-assembly, has a profoundly novel effect on thoughts and efforts related to medicine and pharmacology. This new style of thinking calls for a range of new researches based on new predictions about disease mechanisms (especially autoimmune diseases, endocrinopathies, and neoplasms) and relevant treatment strategies (superstructural pharmaceuticals). Thanks to this new point of view the most fundamental issue in physiology is the quest of how biological systems exert control on the self-assembly of their components and the most fundamental issue in pathology is the quest of how self-assembly of an undesired superstructure triggers a network of events that result in a particular disease state.

Dioctadecyl L-glutamide-derived lipid-grafted silica as a novel organic stationary phase for RP-HPLC.

Dialkyl L-glutamide-derived lipids have been found to form supramolecular assemblies and to show specific properties based on their highly ordered structures in aqueous and organic media. To use these unique properties to create molecular recognition systems, dioctadecyl L-glutamide-derived lipid-grafted porous silica particles (Sil-DSG) were newly prepared and used as a stationary phase in reversed phase liquid chromatography. Compared with conventional ODS (octadecylated silica), the Sil-DSG column showed remarkably higher selectivity for polycyclic aromatic hydrocarbons (PAHs).

Conformational effect of silica-supported poly(octadecyl acrylate) on molecular-shape selectivity of polycyclic aromatic hydrocarbons in RP-HPLC.

Poly(octadecyl acrylate) with a terminal reactive group was synthesized by radical telomerization in various solvents. The polymers were grafted onto porous silica for use in RP-HPLC, and the molecular recognition ability was investigated along with the selectivity for the structural isomers of polycyclic aromatic hydrocarbons. The mechanism of selectivity was also investigated with differential scanning calorimetry and NMR spectroscopic observations.