Publications by authors named "Mahmud Ozkut"
Article Synopsis
- - The study explored how a monoacylglycerol lipase inhibitor, KML-29, affects increased levels of 2-arachidonoylglycerol (2-AG) in a rat model of ovarian ischemia-reperfusion injury, with various groups receiving different treatments.
- - Results showed that treatment with KML-29 reduced ovarian damage and preserved ovarian reserve by decreasing inflammatory markers and apoptotic cell death compared to the ischemia-only group.
- - The findings suggest that increasing 2-AG levels through endocannabinoids could be a potential therapeutic strategy for protecting ovarian function in conditions that affect its reserve.
Article Synopsis
- * JZL184 treatment resulted in improved ovarian health indicators, including increased hormone levels, higher primordial follicle counts, and reduced histopathological damage, while also decreasing oxidative stress and inflammatory markers in the ovaries.
- * The findings suggest JZL184 could be a promising new treatment option to protect against ovarian damage caused by IRI, acting as an antioxidant and anti-inflammatory agent.
Abdominal surgery is linked with peritoneal adhesions. We investigated that the anti-fibrotic agent pirfenidone (PFD) has immune modulating activities and evaluated its effects on the function of T helper type 1 (Th1), Th2 and T regulatory (Treg) cells, which may play important roles in peritoneal adhesions. Eighteen female Wistar rats underwent right-sided parietal peritoneal and right uterine horn adhesion model.
View Article and Find Full Text PDFAim: To study the efficacy of pirfenidone for prevention of postoperative adhesion formation in an adhesion rat model.
Materials And Methods: Eighteen female Wistar rats were subjected to right-sided parietal peritoneum and right uterine horn adhesion model. Rats were randomized into three groups: group 1 (control) (closure of midline abdominal incision without any agent administration), group 2 (closure of incision after intraperitoneal administration of pirfenidone), and group 3 (closure of incision and only oral administration of pirfenidone for 14 days).
Metranidazole (MTZ) is an antibiotic used for parasitic infections in a number of species. Accumulation of this drug in the environment and its interaction with fish of economic value makes this drug particularly important. In the present study, we examined the histopathological effects of MTZ on the intestinal tissue of Oncorhynchus mykiss.
View Article and Find Full Text PDFEffects of Ginkgo biloba on experimental rapid maxillary expansion model: a histomorphometric study.
Oral Surg Oral Med Oral Pathol Oral Radiol
December 2012
Objective: We aimed to investigate the effect of systemic Ginkgo biloba in rapid maxillary expansion (RME).
Study Design: We randomly divided 24 rats into 3 groups: expansion only (EO), expansion plus Ginkgo biloba (GB), and no expansion (NE). Expansion appliances were affixed to the maxillary incisors.
Objective: The aim of this study was to evaluate the effect of systemic thymoquinone (TQ) in a rat rapid maxillary expansion (RME) study.
Design: Thirty-two Wistar albino rats were divided into 4 equal groups: only-expansion (OE), expansion plus TQ (TQ1 group, TQ given to the rats during their nursery phase and during the expansion and retention period), expansion plus TQ (TQ2 group, TQ given to the rats only during the retention period), and control group (no procedure done). Expansion appliances were placed on the maxillary incisors of all animals for 5days.
The aim of this study was to evaluate the effects of 820-nm diode laser on osteoclastic and osteoblastic cell proliferation-activity and RANKL/OPG release during orthodontic tooth movement. Thirty-eight albino Wistar rats were used for this experiment. Maxillary incisors of the subjects were moved orthodontically by a helical spring with force of 20 g.
View Article and Find Full Text PDF