Publications by Mahmud Mustafa Ozkut

Publications by authors named "Mahmud Mustafa Ozkut"

Int Immunopharmacol

May 2023

- The study investigates the impact of TRPV1 channels on Alzheimer's Disease (AD), focusing on how capsaicin (a TRPV1 agonist) and capsazepine (a TRPV1 antagonist) affect neurodegeneration and memory in a rat model induced by okadaic acid.
- Administering okadaic acid increased harmful brain markers and led to impaired spatial memory, while capsaicin treatment reversed these negative effects, unlike capsazepine, which did not show similar benefits.
- The findings suggest that capsaicin can help alleviate neurodegeneration and inflammation in an AD model, potentially highlighting the therapeutic role of TRPV1 activation in cognitive decline.

Cannabis Cannabinoid Res

April 2024

- The study explored how a monoacylglycerol lipase inhibitor, KML-29, affects increased levels of 2-arachidonoylglycerol (2-AG) in a rat model of ovarian ischemia-reperfusion injury, with various groups receiving different treatments.
- Results showed that treatment with KML-29 reduced ovarian damage and preserved ovarian reserve by decreasing inflammatory markers and apoptotic cell death compared to the ischemia-only group.
- The findings suggest that increasing 2-AG levels through endocannabinoids could be a potential therapeutic strategy for protecting ovarian function in conditions that affect its reserve.

J Obstet Gynaecol Res

August 2021

* JZL184 treatment resulted in improved ovarian health indicators, including increased hormone levels, higher primordial follicle counts, and reduced histopathological damage, while also decreasing oxidative stress and inflammatory markers in the ovaries.
* The findings suggest JZL184 could be a promising new treatment option to protect against ovarian damage caused by IRI, acting as an antioxidant and anti-inflammatory agent.