RCT of montelukast as prophylaxis for upper respiratory tract infections in children.

Background: Infections with viruses causing upper respiratory tract infection (URI) are associated with increased leukotriene levels in the upper airways. Montelukast, a selective leukotriene-receptor antagonist, is an effective treatment of asthma and allergic rhinitis.

Objective: To determine whether prophylactic treatment with montelukast reduces the incidence and severity of URI in children.