The relationship between optical coherence tomography and magnetic resonance imaging measurements in people with multiple sclerosis: A systematic review and meta-analysis.

Background: Several studies show that optical coherence tomography (OCT) metrics e with cognition, disability, and brain structure in people with multiple sclerosis (PwMS). This review the correlation between OCT parameters and magnetic resonance imaging (MRI) measurements in PwMS.

Methods: A comprehensive search of PubMed/MEDLINE, Embase, Scopus, and Web of Science was performed, including studies published in English up to November 29, 2024 to identify studies reporting quantitative data on the correlation between baseline OCT parameters and MRI measurements in PwMS.

Association between diffusion tensor imaging measurements and cognitive performances in people with multiple sclerosis: A systematic review and meta-analysis.

Background: Alterations in structural connectivity of brain networks have been linked to complex cognitive functions in people with multiple sclerosis (PwMS). However, a definitive consensus on the optimal diffusion tensor imaging (DTI) markers as indicators of cognitive performance remains incomplete and inconclusive. This systematic review and meta-analysis aimed to explore the evidence on the correlation between DTI metrics and cognitive functions in PwMS.

Functional MRI and cognition in multiple sclerosis-Where are we now?

Multiple sclerosis-related cognitive impairment (MSrCI) affects most patients with multiple sclerosis (MS), significantly contributing to disability and socioeconomic challenges. MSrCI manifests across all disease stages, mainly impacting working memory, information processing, and attention. To date, the underlying mechanisms of MSrCI remain unclear, with its pathogenesis considered multifactorial.

Atypical and giant proliferating pilomatrixoma of the eyelid: a clinicopathological report.

Background: Pilomatrixoma is an uncommon benign skin neoplasm originating from the hair follicle. Here, we report a rare case of giant and atypical proliferating pilomatrixoma affecting the eyelid.

Case Presentation: A 47-year-old male presented with a solitary, giant mass on his left upper eyelid, which had recently shown progressive enlargement.

Development and Validation of a Highly Sensitive RT-qLAMP Assay for Rapid Detection of SARS-CoV-2: Methodological Aspects.

Specific and reliable diagnostic methods are becoming increasingly essential to identify patients in light of the high transmission rate and the recent appearance of the new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For the specific detection of SARS-CoV-2, our quantitative reverse transcription loop-mediated isothermal amplification (RT-qLAMP) assay implementation demonstrates how flexible it can be with two readouts: visualized colorimetric and real-time fluorescence. Different factors were optimized to improve the reaction conditions, including temperature (60 °C), assay runtime (60 min), primers, MgSO (6 mM), dNTPs (1 mM), LAMP Buffer (1.

Microbial natural compounds and secondary metabolites as Immunomodulators: A review.

Immunomodulatory therapies are beneficial strategies for the improvement of immune system function. Today, due to the increasing prevalence of immune disorders, cancer, and new viral diseases, there is a greater need to introduce immunomodulatory compounds with more efficiency and fewer side effects. Microbial derivatives are fertile and attractive grounds for discovering lots of novel compounds with various medical properties.

Utilizing silica fume and synthetically produced mesoporous silicas for simulated flue gas CO adsorption.

Carbon capture and storage (CCS) is crucial in mitigating greenhouse gas emissions. Solid adsorbents, notable for their reusability and corrosion resistance, are gaining attention in CO gas separation. This study uses Silica fume as an adsorbent and silica source for SiO and MCM-41 silica-based adsorbents.

The effect of educational intervention according to mindfulness on the psychological well-being of female heads of households.

Objective: The low level of psychological well-being is one of the most common problems of the women who are the heads of households, and various educational programs have been conducted to improve the psychological well-being of such a group. The present study was conducted to outline the effectiveness of mindfulness-based educational intervention in the psychological well-being of women as the heads of households.

Methods: This research as a semi-experimental study was done by pretest-posttest design and control group.

Navigating the future: Microfluidics charting new routes in drug delivery.

Microfluidics has emerged as a transformative force in the field of drug delivery, offering innovative avenues to produce a diverse range of nano drug delivery systems. Thanks to its precise manipulation of small fluid volumes and its exceptional command over the physicochemical characteristics of nanoparticles, this technology is notably able to enhance the pharmacokinetics of drugs. It has initiated a revolutionary phase in the domain of drug delivery, presenting a multitude of compelling advantages when it comes to developing nanocarriers tailored for the delivery of poorly soluble medications.

Construction of magnetic MoS/NiFeO/MIL-101(Fe) hybrid nanostructures for separation of dyes and antibiotics from aqueous media.

In this study, MoS/NiFeO/MIL-101(Fe) nanocomposite was synthesized by hydrothermal method and used as an adsorbent for the elimination of organic dyes and some antibiotic drugs in aqueous solutions. The synthesized nanocomposite underwent characterization through different techniques, including scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), Brunauer-Emmett-Teller (BET) surface area analysis, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), zeta potential analysis, vibrating sample magnetometry (VSM), and UV-vis diffuse reflectance spectroscopy (UV-vis DRS). These results demonstrated the successful insertion of MoSwithin the cavities of MIL-101(Fe).

Asthma and chronic obstructive pulmonary disease (COPD) in people with multiple sclerosis: A systematic review and meta-analysis.

Background: Studies have found that multiple sclerosis (MS) has an impact on the initiation or the course of asthma and chronic obstructive pulmonary disease (COPD). This review amied to investigate the prevalence and odds of asthma and COPD among people with MS (pwMS).

Method: PubMed, Embase, Scopus, and Web of Science were systemically searched from inception to May 2023.

Alemtuzumab-induced petechiae and epistaxis in a patient with relapsing-remitting multiple sclerosis: A case report.

Here, we present a case of relapsing-remitting multiple sclerosis that experienced petechiae and epistaxis following treatment with second dose of alemtuzumab. This study highlights such effects, emphasizing the need for vigilance as alemtuzumab usage increases. Timely recognition and management are vital for patient care.

Comparison of dynamic and static balance among professional male soccer players by position.

Purpose: Balance is an important performance aspect of all athletes. The aim of this study was to compare static and dynamic balance in soccer players in different positions.

Methods: Forty youth and young adult professional soccer players were divided into four groups according to their playing positions: goalkeepers (GK), defenders (DF), midfielders (MF) and forwards (FW) (10 per position).

XRayWizard: Reconstructing 3-D lung surfaces from a single 2-D chest x-ray image via Vision Transformer.

Background: Chest x-ray is widely utilized for the evaluation of pulmonary conditions due to its technical simplicity, cost-effectiveness, and portability. However, as a two-dimensional (2-D) imaging modality, chest x-ray images depict limited anatomical details and are challenging to interpret.

Purpose: To validate the feasibility of reconstructing three-dimensional (3-D) lungs from a single 2-D chest x-ray image via Vision Transformer (ViT).

Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds.

Histone deacetylases (HDAC) represent promising epigenetic targets for several diseases including different cancer types. The HDAC inhibitors approved to date are pan-HDAC inhibitors and most show a poor selectivity profile, side effects, and in particular hydroxamic-acid-based inhibitors lack good pharmacokinetic profiles. Therefore, the development of isoform-selective non-hydroxamic acid HDAC inhibitors is a highly regarded field in medicinal chemistry.

Effect of Trans-Anethole on Gene Expression of Steroidogenic Enzymes in the Ovary of Polycystic Ovary Syndrome Model Rate:

Background: The process of steroidogenesis is crucial to the normal function of the ovaries. In individuals with polycystic ovary syndrome (PCOS), the activity of related enzymes in this process is disrupted. In the present study, the effect of trans-anethole was investigated on gene expression of steroidogenesis enzymes in PCOS model rats.

Effect of continuous in-feed administration of tylosin to feedlot cattle on macrolide and tetracycline resistant enterococci in a randomized field trial.

Liver abscess causes substantial economic loss to the beef cattle industry through liver condemnation, reduced animal performance, and carcass yield. Continuous in-feed use of tylosin is the most effective and a commonly used practice in beef cattle production to prevent liver abscess. However, such mass medication can increase the level of antimicrobial resistant bacteria.

Computational study of inclusion complexes of V-type nerve agents (VE, VG, VM, VR and VX) with β-cyclodextrin.

The effective detoxification of organophosphate (OP) nerve agents (OPNAs) is a challenging issue for scientists. The host-guest inclusion complexes of five V-type nerve agents (VE, VG, VM, VR and VX) with β-cyclodextrin (β-CD) have been studied by combining quantum mechanical (QM) calculations and molecular dynamics (MD) simulations. The frontier molecular orbital (FMO) and molecular electrostatic potential (MEP) have been analyzed to describe the reactivity parameters and electronic properties.

Preventive and therapeutic use of herbal compounds against doxorubicin induced hepatotoxicity: a comprehensive review.

Doxorubicin (DOX) is associated with numerous acute and chronic dose-related toxicities including hepatotoxicity. This adverse reaction may limit the use of other chemotherapeutic agents with hepatic excretion, and so, its prevention is an important issue. The aim of this study was to conduct a comprehensive review of in vitro, in vivo and human studies regarding the protective effects of synthetic and naturally-occurring compounds against DOX-induced liver injury.

Extracellular vesicles of immune cells; immunomodulatory impacts and therapeutic potentials.

Extracellular vesicles (EVs) are a diverse collection of lipid bilayer-membrane-bound particles which are released from cells into the extracellular space and biologic fluids. In multicellular organisms, these vesicles facilitate the exchange of bioactive compounds such as RNA, DNA, proteins, various metabolites, and lipids between the cells. EVs are produced and released by almost all eukaryotic cells including immune cells and can have immunomodulating effects by either stimulation or suppression of their activities.

How much should you worry about contaminant neutrons in spatially fractionated grid radiation therapy?

Neutron contamination in radiation therapy is of concern in treatment with high-energy photons (> 10 MV). With the development of new radiotherapy modalities such as spatially fractionated grid radiation therapy (SFGRT) or briefly grid radiotherapy, more studies are required to evaluate the risks associated with neutron contamination. In 15 MV SFGRT, high-Z materials such as lead and cerrobend are used as the block on the tray of linear accelerator (linac) which can probably increase the photoneutron production.

A Multi-Criteria Approach for Comparison of Ginger Extract and Conventional Irrigants in Root Canal Treatment.

Background Considering the importance of irrigation in dental root canal treatment, there is an urgent need to find a risk-free bioactive and antibacterial endodontic solution. , an anaerobic gram-positive coccus, has been identified as the main reason for endodontic infections. Several studies have been conducted on and periapical infection.

Opinion texts summarization based on texts concepts with multi-objective pruning approach.

Considering the huge volume of opinion texts published on various social networks, it is extremely difficult to peruse and use these texts. The automatic creation of summaries can be a significant help for the users of such texts. The current paper employs manifold learning to mitigate the challenges of the complexity and high dimensionality of opinion texts and the K-Means algorithm for clustering.