Publications by authors named "Mahmoud Zyoud"
Background: Type 1 diabetes is the most common type of diabetes mellitus (DM) in children. It can be sporadic in onset or cluster in families, which comprises parent-offspring and sib-pair subgroups. The risk of developing DM in first-degree relatives of affected individuals is 8-15 fold higher.
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- The study aims to analyze various aspects of type 2 diabetes in individuals under 18, including its epidemiology, clinical signs, and biochemical markers.
- From 2018 to 2020, researchers evaluated 104 young patients, revealing a higher prevalence and incidence of type 2 diabetes, primarily affecting Qatari males, with a significant correlation to obesity and maternal gestational diabetes.
- The findings emphasize the need for preventive measures targeting childhood obesity and maternal health to mitigate future health complications associated with early-onset type 2 diabetes in Qatar.
To describe the clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus (T1DM). Patients (0-18 years) with diabetes were recruited. Clinical data was collected, autoantibodies and c-peptide were measured.
View Article and Find Full Text PDFContext: Idiopathic type 1 diabetes is characterized by the absence of autoantibodies and the underlying mechanisms are not clear.
Objective: We aimed to study the epidemiology, describe the clinical characteristics, and report results of genetic studies in pediatric patients with idiopathic type 1 diabetes.
Methods: This was a prospective study of type 1 diabetes patients attending Sidra Medicine from 2018 to 2020.
Objectives: Children with antibody positive type 1 diabetes mellitus (type 1 diabetes) are at an increased risk of developing celiac disease (CD) which suggests a common autoimmune basis with both high-risk human lymphocyte antigen (HLA) and non-HLA factors playing a role in the pathophysiology. We aim to describe the prevalence, immune profile, and clinical characteristics of children with CD who have type 1 diabetes mellitus in Qatar.
Methods: All children (aged 0-18 years) attending a regional diabetes clinic with antibody positive type 1 diabetes were screened for CD.
Article Synopsis
- The study investigates childhood diabetes mellitus in Qatar, focusing on its epidemiology, genetic factors, and causes among patients aged 0-18.
- A total of 1,325 children were diagnosed with various types of diabetes, with type 1 being the most prevalent, and significantly higher incidence rates were noted in Qatari children compared to other nationalities.
- The research highlights Qatar's notable statistics regarding diabetes, including the fourth highest incidence of type 1 diabetes globally and an alarming prevalence of type 2 diabetes compared to Western countries.
Article Synopsis
- Corneal confocal microscopy is a non-invasive technique used to measure corneal nerve structures to investigate nerve damage in children with type 1 diabetes compared to healthy peers.
- The study involved 20 diabetic participants averaging 14 years old and 20 healthy controls, measuring several nerve metrics such as density and length using microscopy.
- Results showed significant reductions in corneal nerve fiber density, branch density, fiber length, and inferior whorl length in diabetic children, indicating subclinical nerve loss despite no visible complications like retinopathy.
The objective of the study was to determine the degree of linear growth retardation of patients with vitamin D deficiency rickets at presentation and the magnitude of catch-up growth in relation to their calcium (Ca) homeostasis and hormones affecting it before and after treatment. This prospective study recorded the anthropometric data and measured the circulating 25-hydroxy vitamin D (25-OH-D), insulin-like growth factor I (IGF-I), parathyroid hormone, Ca, phosphate, and alkaline phosphatase concentrations in 46 infants and children with nutritional (vitamin D deficiency) rickets before and 6 months or more after treatment with one intramuscular injection of vitamin D3 megadose (300000 IU). Forty normal age- and sex-matched children were included as controls for the auxological data.
View Article and Find Full Text PDFDuplications of Xq26-27 have been implicated in the etiology of X-linked hypopituitarism associated with mental retardation (MR). Additionally, an expansion of a polyalanine tract (by 11 alanines) within the transcription factor SOX3 (Xq27.1) has been reported in patients with growth hormone deficiency and variable learning difficulties.
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