Publications by authors named "Mahmoud R Mohamed"
Article Synopsis
- Hepatocellular carcinoma (HCC) is the most common liver cancer, often caused by chronic hepatitis and cirrhosis, with this study aiming to examine the genomic characteristics of HCC in Egyptian patients through whole exome sequencing.
- Whole exome sequencing was performed on 13 HCC patients who underwent surgery, revealing specific mutational signatures and a set of highly mutated genes associated with HCC, including notable mutations in APOB and RP1L1 across multiple studies.
- The findings confirmed previously established patterns in HCC genetics, identifying critical signaling pathways and potential clinical targets, highlighting the importance of these mutations for future research and therapy development.
Background: () biofilm is grown not only on medical devices but also on different substrata and is considered a potential hazard in the food industry. Quorum sensing plays a serious role in the synthesis of biofilm with its surrounding extracellular matrix enabling irreversible connection of the bacteria.
Aim: The goal of the current investigation was to ascertain the prevalence, patterns of antimicrobial resistance, and capacity for biofilm formation in meat and meat products in Egypt.
Background: Globally, there are regional and time-based variations in the prevalence, etiology, and prognosis of rapidly progressive glomerulonephritis (RPGN). Prognosis of RPGN is poor, with a higher risk of death and end stage renal disease (ESRD) even with immunosuppressive medications. In the Middle East and North Africa, the studies on this disease are very limited.
View Article and Find Full Text PDFDown-regulation of hepatic expression of GHR/STAT5/IGF-1 signaling pathway fosters development and aggressiveness of HCV-related hepatocellular carcinoma: Crosstalk with Snail-1 and type 2 transforming growth factor-beta receptor.
PLoS One
November 2022
Background And Aims: So far, few clinical trials are available concerning the role of growth hormone receptor (GHR)/signal transducer and activator of transcription 5 (STAT5)/insulin like growth factor-1 (IGF-1) axis in hepatocarcinogenesis. The aim of this study was to evaluate the hepatic expression of GHR/STAT5/IGF-1 signaling pathway in hepatocellular carcinoma (HCC) patients and to correlate the results with the clinico-pathological features and disease outcome. The interaction between this signaling pathway and some inducers of epithelial-mesenchymal transition (EMT), namely Snail-1 and type 2 transforming growth factor-beta receptor (TGFBR2) was studied too.
View Article and Find Full Text PDFArticle Synopsis
- * It is particularly effective at detecting small liver lesions that standard imaging methods like CT and MRI often overlook.
- * Proper positioning during EUS is vital for procedures like tumor ablation and measuring portal pressure, highlighting the need for a strong understanding of liver anatomy in these interventions.