A comparative randomized clinical trial evaluating the efficacy and safety of tacrolimus versus hydrocortisone as a topical treatment of atopic dermatitis in children.

Atopic dermatitis (AD) aetiology is not exactly identified, but it is characterized by pruritic skin reactions with elevation in the levels of inflammatory markers. Despite the fact that Corticosteroids are the mainstay therapy in the management of AD, they have many local and systemic adverse effects. The aim of this study is to evaluate the efficacy and safety of topical tacrolimus ointment in comparison to topical hydrocortisone cream in the management of the AD of children diagnosed with AD.

Isotretinoin Induced Hyperlipidemia and Impact of Leptin Gene 7799039 Polymorphism in Safety of Acne Patients.

Background: Acne vulgaris (AV) is a chronic inflammatory disease that affects the pilosebaceous unit. Leptin (LEP) gene polymorphisms is associated with higher risk of multiple disorders. Insulin-like growth factor-1 (IGF-1) exerts comedogenic effect by stimulating the sebaceous glands.

Coenzyme Q10 phospholipidic vesicular formulations for treatment of androgenic alopecia: permeation and clinical appraisal.

Introduction: Coenzyme Q10 (CoQ10) is an antioxidant molecule with anti-aging activity on human hair, and because of its pharmaceutical limitations such as large molecular weight, high lipophilicity and poor water solubility, its therapeutic effectiveness has been hampered. Therefore, different vesicular nanocarriers were developed in the current work, for enhancement of the skin penetration of CoQ10 for treatment of androgenic alopecia.

Areas Covered: In order to overcome the poor skin penetration of CoQ10, it was formulated in liposomes, transfersomes, ethosomes, cerosomes and transethosomes using the thin-film hydration method.

The impacts of different heating systems on the environment: A review.

This paper presents a review of the environmental impacts of most heating systems drawing together published literature on the subject, not previously available. Here, a comparison between the different systems such as coal, wood, oil, natural gas, heat pump, geothermal and solar energy is provided in terms of their environmental impact. The most important parameters considered are the emission rate and toxicity.