Publications by authors named "Mahmoud M Morsy"
Introduction: Idiopathic intracranial hypertension (IIH) has been traditionally viewed as a neuro-ophthalmic disorder, yet emerging evidence suggests broader systemic implications. Our study investigates the cardiometabolic outcomes associated with IIH through a comprehensive matched-cohort analysis.
Methods: We conducted a retrospective analysis of electronic health records from 2009 to 2024.
Background: Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by elevated intracranial pressure, predominantly affecting young women with obesity. This study evaluates the effectiveness of semaglutide as an adjunctive therapy to standard IIH management using real-world data.
Methods: We conducted a retrospective cohort analysis comparing IIH patients receiving semaglutide plus standard therapy versus standard therapy alone.
Introduction: Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by elevated intracranial pressure, predominantly affecting obese women of reproductive age. While GLP-1 receptor agonists have shown promise in IIH management, the potential of dual GIP/GLP-1 receptor activation through tirzepatide remains unexplored. This study aimed to evaluate tirzepatide's efficacy as an adjunctive therapy in IIH management.
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- The study investigates the effectiveness of Endovascular Thrombectomy (EVT) versus Best Medical Treatment (BMT) for patients with large core ischemic infarcts, analyzing data from six randomized control trials (RCTs) involving 1918 patients.
- Results show that EVT combined with BMT significantly improves 90-day outcomes, yielding higher rates of favorable results (mRS scores), lower mortality rates, and better neurological recovery compared to BMT alone, although it also increases the risk of symptomatic intracerebral hemorrhage (sICH).
- Specifically, EVT led to a notable absolute improvement in mRS scores (0-1, 0-2, 0-3) by
Introduction: Acute myeloid leukemia (AML) is a significant hematological malignancy in the United States, with a high mortality rate and limited treatment options. CAR T-cell therapy, a new and promising treatment, is being investigated for its efficacy and safety in AML. This meta-analysis aims to assess the safety and efficacy of CAR T-cell therapy in AML, considering various subgroups such as study location, study design, prior transplantation status, conditioning regimen, and CAR T-cell source.
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- Idiopathic intracranial hypertension (IIH) mainly affects obese women of reproductive age and is marked by high intracranial pressure; venous sinus stenting (VSS) is a surgical option, though its safety and effectiveness are debated.
- A systematic review included 36 studies with 1066 patients who underwent VSS, showing significant reductions in intracranial pressure and improvements in symptoms like tinnitus and visual disturbances, but with notable rates of treatment failure (8.35%) and complications (5.35%).
- Overall, VSS may be a viable treatment for IIH patients unresponsive to other therapies, but more research is needed to assess long-term safety and outcomes.
Liver diseases and its complications is common health problem worldwide. The emergence of metabolic disorders as a cause after exclusion of viral hepatitis nowadays is important. This is retrospective study on 200 patient's age range from 6months to 18 years old (50 females and 150 males).
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