Publications by authors named "Mahmoud M Bashir"
Transfer RNAs (tRNAs) are fundamental for both cellular and viral gene expression during viral infection. In addition, mounting evidence supports biological function for tRNA cleavage products, including in the control of gene expression during conditions of stress and infection. We previously reported that infection with the model murine gammaherpesvirus, MHV68, leads to enhanced tRNA transcription.
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- Transfer RNAs (tRNAs) are crucial for gene expression in cells and viruses, and recent findings suggest tRNA fragments play a role in responding to stress and infections.
- In studying the murine gammaherpesvirus (MHV68), researchers used advanced sequencing techniques to analyze how viral infection changes tRNA and tRNA-derived RNA (tDR) levels, revealing specific cleavage of tRNAs during the infection.
- The study found that tRNA splicing factors are involved in creating these tRNA cleavage products, impacting the production of infectious virus, and highlighting the importance of tRNA processing in gammaherpesvirus infections.