Publications by authors named "Mahmoud Khatib A A Al-Ruweidi"
Purpose: This study examines the effect of antihypertensive drugs on ACE2 and Angiotensin II levels in hypertensive COVID-19 patients.
Introduction: Hypertension is a common comorbidity among severe COVID-19 patients. ACE2 expression can be modulated by antihypertensive drugs such as ACEis and ARBs, which may affect COVID-19's prognosis.
Article Synopsis
- Plant-based materials are increasingly used in packaging due to their biodegradability, sustainability, and cost-effectiveness, replacing traditional polymers like polyethylene.
- Poly(lactic acid) (PLA) is highlighted as a popular eco-friendly polymer with strong chemical and mechanical properties, making it suitable for packaging applications.
- In this study, PLA was modified with food additives (ascorbic acid and fumaric acid) using plasma-initiated grafting, resulting in improved adhesion properties, with peel resistance increasing by 74% and 184% for the modified samples.
The SARS-CoV-2 virus utilizes angiotensin converting enzyme () for cell entry and infection. This enzyme has important functions in the renin-angiotensin aldosterone system to preserve cardiovascular function. In addition to the heart, it is expressed in many tissues including the lung, intestines, brain, and kidney, however, its functions in these organs are mostly unknown.
View Article and Find Full Text PDFWith the recent SARS-CoV-2 outbreak, the importance of rapid and direct detection of respiratory disease viruses has been well recognized. The detection of these viruses with novel technologies is vital in timely prevention and treatment strategies for epidemics and pandemics. Respiratory viruses can be detected from saliva, swab samples, nasal fluid, and blood, and collected samples can be analyzed by various techniques.
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- - Many patients with pulmonary diseases require mechanical ventilation (MV), which can lead to ventilation-induced lung injuries (VILIs) due to stress on the delicate lung epithelium, especially in those with acute respiratory distress syndrome (ARDS).
- - Researchers propose a new method to protect epithelial cells during MV by altering their cytoskeletal structure, testing the anti-inflammatory drugs dexamethasone (DEX) and transdehydroandrosterone (DHEA) for their effects on cell survival under stress.
- - Their findings show that preexposing cells to DEX or DHEA significantly reduces cell death caused by MV, suggesting a potential treatment approach for ARDS in patients, including those affected by COVID-
Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications usually involve the generation of continuous and steady fluid flow over cell monolayers for extended durations, usually a few days. Another technique is to generate a fast high-stress wave over the cells to see the immediate effect of flow-induced stresses.
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