Publications by authors named "Mahmoud H Yousef"
Treatment of 3-phenyl-1,3-thiazolidin-4-one derivative 1 with phenylisothiocyanate in DMF, in the presence of potassium hydroxide, at room temperature gave the non-isolable potassium salt 2. The in-situ reaction of 2 with differently substituted N-aryl hydrazonoyl chlorides 3, 7a-d and 14a-d afforded the corresponding 2-(pyrazolyl)thiazolylimino-5-(thiadiazolylidene)thiazolidin-4-one derivatives 6, 10a-d and 17a-d, respectively. Reaction of 2 with further α-haloketones yielded the 4-(pyrazolyl)thiazolylimino-bis-thiazolidine derivatives 22, 25 and 26.
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- A compound called N-(4-(Pyrazol-4-yl)thiazol-2-yl)-N'-phenylthiourea was synthesized and reacted with different hydrazonoyl chlorides to create several derivatives with potential anticancer properties.
- The synthesis also involved reactions with ethyl chloroacetate and a specific diketone, leading to the formation of thiazolidin-4-one and 1,3-thiazole derivatives.
- Testing of these newly synthesized compounds against various cancer cell lines revealed that many exhibited moderate to high anticancer activity, with effectiveness influenced by the presence of different chemical groups.