Hepatitis E virus (HEV) open reading frame 2: Role in pathogenesis and diagnosis in HEV infections.

Hepatitis E virus (HEV) infection occurs worldwide. The HEV genome includes three to four open reading frames (ORF1-4). ORF1 proteins are essential for viral replication, while the ORF3 protein is an ion channel involved in the exit of HEV from the infected cells.