CASR, CLDN 14, ALPL & SLC34A1 genes are associated with the risk of nephrolithiasis in Egyptian children.

Backgrounds: The pathophysiology of nephrolithiasis is complex, influenced by both environmental and genetic factors. Calcium is the most prevalent metabolite present in the stone matrix. Stimulating the basolateral calcium sensing receptor (CASR) in the renal tubules leads to an increase in claudin-14 expression, reducing paracellular calcium permeability and increasing urinary Ca excretion.

Evaluation of the antibacterial and antibiofilm effect of mycosynthesized silver and selenium nanoparticles and their synergistic effect with antibiotics on nosocomial bacteria.

Background: The healthcare sector faces a growing threat from the rise of highly resistant microorganisms, particularly Methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Pseudomonas aeruginosa (MDR P. aeruginosa). Facing the challenge of antibiotic resistance, nanoparticles have surfaced as promising substitutes for antimicrobial therapy.

Impact of short and long-term application of low-level laser therapy on mandibular alveolar process of osteoporotic rats - a Histological and Molecular Study.

This study aims to investigate and compare the effects of short and long-term application of low-level laser therapy on the mandibular alveolar process of osteoporotic rats. Forty adult male albino rats were included in this study. After animal grouping, the experimental group received dexamethasone (0.

Remodeling the Inflammatory and Immunosuppressive Tumor Microenvironment for Enhancing Antiangiogenic Gene Therapy of Colorectal Cancer.

Fusobacterium nucleatum (Fn), as an intestinal pathogenic bacterium, is closely related to the occurrence, progression, and limited therapeutic efficacy of colorectal cancer (CRC). The presence of Fn within CRC communities induces an inflammatory and immunosuppressive microenvironment while promoting new vessel formation. Therefore, developing novel methods to efficiently eliminate Fn and enhance the therapeutic outcomes against Fn-associated CRC is of great significance.

Antifungal effect of Algerian essential oil nanoemulsions to control and in Thomson Navel oranges ( L. Osbeck).

Fungal infection is a potential issue in citrus fruits, while essential oils from and could be better alternatives to synthetic fungicides in orange preservation. The nanoparticles produced during ultrasonication exhibited a monomodal distribution of particle sizes with a mean zeta potential and a polydispersity index mean value of 74.12 nm, -38.

Disease Risk Score Derivation and Validation in Abu Dhabi, United Arab Emirates: A Retrospective Cohort Study.

Background: Cardiovascular disease risk assessment is a key tool in primary prevention. The ADRS (Abu Dhabi Risk Study) is a retrospective cohort study aiming to develop 10-year risk prediction equations for coronary artery disease (CAD), stroke, and atherosclerotic cardiovascular disease (ASCVD), and validate international risk equations.

Methods And Results: The 8699 participants were examined in the Abu Dhabi cardiovascular screening program from 2011 to 2013 with a subsequent average follow-up of 9.

Bio-computational modeling, POM analysis and molecular dynamic simulation for novel synthetic quinolone and benzo[d][1,3]oxazine candidates as antimicrobial inhibitors.

The current study offers a metal-free, direct, and successful synthesis technique for a new series of quinolinone and benzo[d][1,3]oxazine, along with an assessment of their biological activities. Heteroannulation of anthranilic acid with carbonyl-containing chemicals (aroyl pyruvate, ethyl acetoacetatete, maleic anhydride, and ethyl cyanoacetate) resulted in the desired quinolones and benzo[d][1,3]oxazines. This technique introduces a number of fundamental breakthroughs in organic synthesis, including metal-free catalysts, smart reaction conditions with column purification, and a wide functional scope.

Promoting tomato resilience: effects of ascorbic acid and sulfur-treated biochar in saline and non-saline cultivation environments.

The resilience of tomato plants under different cultivation environments, particularly saline and non-saline conditions, was investigated by applying various treatments, including 0.5% Ascorbic Acid (AsA) and 1% Sulphur-treated Biochar (BS). The study evaluated parameters such as fruit length, diameter, yield per plant and pot, Total Soluble Solids (TSS) content, chlorophyll content, electrolyte leakage, enzyme activities (Superoxide Dismutase - SOD, Peroxidase - POD, Catalase - CAT), and nutrient content (Nitrogen - N%, Phosphorus - P%, Potassium - K%).

A prospective randomized-controlled non-blinded comparative study of the JAK inhibitor (baricitinib) with TNF-α inhibitors and conventional DMARDs in a sample of Egyptian rheumatoid arthritis patients.

To evaluate the efficacy of baricitinib compared to TNF-α Inhibitors and conventional DMARDs (cDMARDs) in patients with RA. Our study included 334 RA patients classified into 3 groups: the first receiving baricitinib, the second receiving TNF-α Inhibitors, and the third receiving cDMARDs. Patients were evaluated at baseline, week 12, and week 24 using TJC, SJC, VAS, DAS28, CDAI, and HAQ-DI.

Forecasting mortality and DALYs from air pollution in SAARC nations.

This study investigates the projected impact of air pollution on mortality and Disability-Adjusted Life Years (DALYs) across SAARC countries. Utilizing Time Series and Machine Learning methodologies such as Autoregressive Integrated Moving Average, Exponential Smoothing, and Neural Network, the research aims to accurately forecast the mortality and DALYs attributed to air pollution from 2020 to 2030. Statistical analyses reveal a consistent upward trend in deaths and DALYs during the forecasting period, primarily driven by Ambient Particulate Matter Pollution (APM) and Ambient Ozone Pollution (AOP).

Hypertension and its determinants in Abu Dhabi population: a retrospective cohort study.

Background: Preventing high blood pressure and its complications requires identifying its risk factors. This study assessed predictors of hypertension and its associated complications among Emirati adults in Abu Dhabi, United Arab Emirates (UAE).

Methods: This retrospective cohort study was conducted by retrieving data from the Electronic Medical Records (EMR) of Emiratis who participated in a national cardiovascular screening program between 2011 and 2013.

ASSESSMENT OF CIPROFLOXACIN EFFECTS ON SOME CHICKS' ORGANS: A COMPREHENSIVE BIOCHEMICAL AND HISTOLOGICAL STUDY.

The aim is to evaluate ciprofloxacin toxicity in the liver and kidneys by assessing their functioning, histological alterations, and GFAP expression in chicks. In the acute trial, the chicks were divided into 3 groups of six. The 1st was the control.

Investigating the potential of triclinic ABSe (A = Li, Na, K, Rb, Cs; B = Si, Ge, Sn) perovskites as a new class of lead-free photovoltaic materials.

In recent years, chalcogenide perovskites have emerged as promising candidates with favorable structural, electrical, and optical properties for photovoltaic applications. This paper explores the structural, electronic, and optical characteristics of ABSe perovskites (where A = Li, Na, K, Rb, Cs; B = Si, Ge, Sn) in their triclinic crystallographic phases using density functional theory. The stability of these materials is ensured by calculating formation energies, tolerance factors (T), and phonon dispersion.

Exploring the potential of plant astrobiology: adapting flora for extra-terrestrial habitats: a review.

In recent years, the realm of astrobiology has expanded beyond the search for microbial life to encompass the intriguing possibility of plant life beyond our planet. Plant astrobiology delves into the adaptations and mechanisms that might allow Earth's flora to flourish in the harsh conditions of outer space and other celestial bodies. This review aims to shed light on the captivating field of plant astrobiology, its implications, and the challenges and opportunities it presents.

Modeling health outcomes of air pollution in the Middle East by using support vector machines and neural networks.

This study investigates the impact of air pollution on health outcomes in Middle Eastern countries, a region facing severe environmental challenges. As such, these are important in an effort to add up to policy-level as well as interventional changes that can be put in practice in the area of public health. Numeration analysis and association with health parameters was carried out by using Analytical tools such as, AIR Data, ARIMA,ANN, SVM and Exponential smoothing.

Effect of Nano-Zinc Oxide, Rice Straw Compost, and Gypsum on Wheat ( L.) Yield and Soil Quality in Saline-Sodic Soil.

The salinity and alkalinity of soils are two fundamental factors that limit plant growth and productivity. For that reason, a field study conducted at Sakha Agric. Res.

Exploring the role of topological descriptors to predict physicochemical properties of anti-HIV drugs by using supervised machine learning algorithms.

In order to explore the role of topological indices for predicting physio-chemical properties of anti-HIV drugs, this research uses python program-based algorithms to compute topological indices as well as machine learning algorithms. Degree-based topological indices are calculated using Python algorithm, providing important information about the structural behavior of drugs that are essential to their anti-HIV effectiveness. Furthermore, machine learning algorithms analyze the physio-chemical properties that correspond to anti-HIV activities, making use of their ability to identify complex trends in large, convoluted datasets.

Seasonal variations in soil characteristics control microbial respiration and carbon use under tree plantations in the middle gangetic region.

Seasonal variations directly impact the biochemical and microbial properties of the soil, influence carbon and nutrient cycling within the soil system. Soils under tree plantation (TP) are rich in organic matter and microbial population, making them more susceptible to seasonal variation. We studied the effect of seasonal variations in soil chemical properties (pH, electrical conductivity (EC), total organic carbon (TOC), total nitrogen (TN), C/N ratio etc) and microclimate (moisture and temperature) on microbial respiration (SR), biomass, and carbon (C) utilization efficiency under 13 years old Kadamb ( Miq.

Design, synthesis, and antiproliferative activity of new indole/1,2,4-triazole/chalcone hybrids as EGFR and/or c-MET inhibitors.

A novel group of indolyl-1,2,4-triazole-chalcone hybrids was designed, synthesized, and assessed for their anticancer activity. The synthesized compounds exhibited significant antiproliferative activity. Compounds 9a and 9e exhibited significant cancer inhibition with GI ranging from 3.

Computational insights into zinc silicate MOF structures: topological modeling, structural characterization and chemical predictions.

Metal-organic frameworks (MOFs) play a pivotal role in modern material science, offering unique properties such as flexibility, substantial pore space, distinctive structure, and large surface area. Recently, zinc-based MOFs have attracted significant attention, particularly in the biomedical arena, owing to their versatile applications in drug delivery, biosensing, and cancer imaging. However, there remains a crucial need to explore and understand the structural properties of zinc silicate-based MOFs to fully exploit their potential in various applications.