Transition Metal-Catalyzed C-H Activation/Functionalization of 8-Methylquinolines.

8-Methylquinoline is regarded as an ideal substrate to participate in diversely C(sp)-H functionalization reactions. The presence of the chelating nitrogen atom enables 8-methylquinoline to easily form cyclometallated complexes with various transition metals, leading to the selective synthesis of functionalized quinolines. Considering the great importance of quinoline cores in medicinal chemistry, in this review article, we have covered the publications related to the C-H activation and functionalization of 8-methylquinoline under transition metal catalysis during the last decade.

NHC-Catalyzed Enantioselective Transformations Involving α-Bromoenals.

α-Haloenals, especially, α-bromoenals considered as one of the important building blocks in organic synthesis. They can participate in various (3+2)-, (3+3)-, (3+4)-, and (2+4)-annulation reactions with other organic molecules in the presence of an NHC catalyst to produce enantioenriched carbo-, and heterocyclic compounds. Herein, we have described NHC-catalyzed enantioselective transformations of α-bromoenals in the synthesis of various heterocycles, and carbocycles, as well as acyclic organic compounds.