Publications by authors named "Mahmoud Alzyoud"
Article Synopsis
- The study aims to analyze various aspects of type 2 diabetes in individuals under 18, including its epidemiology, clinical signs, and biochemical markers.
- From 2018 to 2020, researchers evaluated 104 young patients, revealing a higher prevalence and incidence of type 2 diabetes, primarily affecting Qatari males, with a significant correlation to obesity and maternal gestational diabetes.
- The findings emphasize the need for preventive measures targeting childhood obesity and maternal health to mitigate future health complications associated with early-onset type 2 diabetes in Qatar.
Article Synopsis
- The study investigates childhood diabetes mellitus in Qatar, focusing on its epidemiology, genetic factors, and causes among patients aged 0-18.
- A total of 1,325 children were diagnosed with various types of diabetes, with type 1 being the most prevalent, and significantly higher incidence rates were noted in Qatari children compared to other nationalities.
- The research highlights Qatar's notable statistics regarding diabetes, including the fourth highest incidence of type 1 diabetes globally and an alarming prevalence of type 2 diabetes compared to Western countries.
Background: Permanent neonatal diabetes mellitus (PNDM) is characterized by the onset of hyperglycemia within the first six months of life. Their diabetes is associated with partial or complete insulin deficiency with variable degree of intrauterine growth retardation. Insulin therapy corrects the hyperglycemia and results in improvement of growth.
View Article and Find Full Text PDFObjectives/design: Comparative cross-sectional study to assess homocysteine and vitamin status in carriers of CBS gene mutations.
Method: Subjects included 34 parents (13 males, 21 females, age 27-59 years) of 30 patients with classical homocystinuria due to homozygous cystathionine beta-synthase deficiency. Control subjects were matched for gender and age (13 males, 21 females, age 25-59 years).
Objective: Familial glucocorticoid deficiency type I (FGD1) is a rare form of primary adrenal insufficiency resulting from recessive mutations in the ACTH receptor (MC2R, MC2R). Individuals with this condition typically present in infancy or childhood with signs and symptoms of cortisol insufficiency, but disturbances in the renin-angiotensin system, aldosterone synthesis or sodium homeostasis are not a well-documented association of FGD1. As ACTH stimulation has been shown to stimulate aldosterone release in normal controls, and other causes of hyponatraemia can occur in children with cortisol deficiency, we investigated whether MC2R changes might be identified in children with primary adrenal failure who were being treated for mineralocorticoid insufficiency.
View Article and Find Full Text PDFDuplications of Xq26-27 have been implicated in the etiology of X-linked hypopituitarism associated with mental retardation (MR). Additionally, an expansion of a polyalanine tract (by 11 alanines) within the transcription factor SOX3 (Xq27.1) has been reported in patients with growth hormone deficiency and variable learning difficulties.
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