The forensic Deoxyribonucleic Acid (DNA) fingerprinting is a tool for investigating crime scenes by identifying/tracing criminals and linking crime scenes. However, in cases where experts are unable to detect and identify any biological traces or human-derived cells at the crime scene or while testing the samples in the laboratories, all the advantages offered by forensic laboratories lose their significance. It becomes a waste of time, effort, and resources allocated to these laboratories.
View Article and Find Full Text PDFThis study reports on the synthesis, characterization, and application of two acidic ionic liquids, namely, -carboxymethylpyridinium acetate ([HOCCHPy][CHCO] or ) and -carboxyethylpyridinium acetate ([HOC(CH)Py][CHCO] or ), as both extractants and catalysts for the oxidative and extractive desulfurization (OEDS) of model fuel oils containing heteroaromatic sulfur compounds. The structural properties of the synthesized acidic ionic liquids (ILs) were confirmed by H NMR, C NMR, and FT-IR spectroscopic analysis. To optimize the performance of the acidic AILs in the desulfurization process, the effects of different parameters, such as HO dosage, reaction time, and temperatures, were investigated.
View Article and Find Full Text PDFIn exploring nature's potential in addressing diabetes-related conditions, this study investigates the therapeutic capabilities of 3-formyl chromone derivatives. Utilizing in silico methodologies, we focus on 6-substituted 3-formyl chromone derivatives (1-16) to assess their therapeutic potential in treating diabetes. The research examined the formyl group at the chromone's C-3 position.
View Article and Find Full Text PDFThe ongoing global concern of cancer worldwide necessitates the development of advanced diagnostic and therapeutic strategies. The majority of recent detection strategies involve the employment of biomarkers. A critical biomarker for cancer immunotherapy efficacy and patient prognosis is Programmed Death Ligand 1 (PD-L1), which is a key immune checkpoint protein.
View Article and Find Full Text PDFIn this study, we synthesized novel α,β-unsaturated 2-cyanoacetamide derivatives () using microwave-assisted Knoevenagel condensation. Characterization of these compounds was carried out using FTIR and H NMR spectroscopy. We then evaluated their in vitro antibacterial activity against both gram-positive and gram-negative pathogenic bacteria.
View Article and Find Full Text PDFThis study investigates the potential of 2-(4-butylbenzyl)-3-hydroxynaphthalene-1,4-dione () and its 12 derivatives as anticancer and biofilm formation inhibitors for methicillin-resistant using methods. The study employed various computational methods, including molecular dynamics simulation molecular docking, density functional theory, and global chemical descriptors, to evaluate the interactions between the compounds and the target proteins. The docking results revealed that compounds , , , and ofloxacin exhibited binding affinities of -7.
View Article and Find Full Text PDFThis laboratory study aimed to evaluate the effect of different surface patterns using femtosecond laser treatment on the enclosed mold shear bond strength (EM-SBS) of resin composite to zirconia (ZrO) surfaces and to contrast it with the widely used tribochemical silica coating (TBC) surface conditioning method. A set of fifteen rectangular ZrO blocks were randomly divided into five groups according to surface pretreatment: Control G-no treatment; G-TBC with silane application; G-femtosecond laser irradiation with horizontal lines 30 µm apart; -femtosecond laser irradiation with horizontal lines 15 µm apart; and G-femtosecond laser irradiation with cross lines 30 µm apart. The pretreated surfaces were characterized by a surface profilometer, tensiometer and scanning electron microscope.
View Article and Find Full Text PDFQuartz tuning forks (QTFs), which were coated with gold and with self-assembled monolayers (SAM) of a lower-rim functionalized calix[4]arene methoxy ester (CME), were used for the detection of benzene, toluene, and ethylbenzene in water samples. The QTF device was tested by measuring the respective frequency shifts obtained using small (100 µL) samples of aqueous benzene, toluene, and ethylbenzene at four different concentrations (10, 10, 10, and 10 M). The QTFs had lower limits of detection for all three aromatic hydrocarbons in the 10 M range, with the highest resonance frequency shifts (±5%) being shown for the corresponding 10 M solutions in the following order: benzene (199 Hz) > toluene (191 Hz) > ethylbenzene (149 Hz).
View Article and Find Full Text PDFThe human cytomegalovirus (HCMV) is an asymptomatic common virus that is typically harmless, but in some cases, it can be life threatening. Thus, there is an urgent need to develop novel diagnostic methods and strengthen the efforts to combat this virus. A microcantilever-based biosensor functionalised with the UL83-antibody of HCMV (UL83-HCMV antibody) has been developed to detect the UL83-antigen of HCMV (UL83-HCMV antigen) at different concentrations ranging from 0.
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