Publications by authors named "Mahmoud Ahmed El-Hawy"
Background: The pathophysiology and susceptibility of children to primary immune thrombocytopenia (ITP) are linked to polymorphisms of the interleukin (IL)-1B and IL-1 receptor (IL-1R) antagonist genes.
Purpose: To investigate the association between the susceptibility and severity of primary ITP in children and the IL-1B and IL-1R antagonist gene polymorphisms.
Methods: This comparative case-control study was conducted at the Menoufia University Hospital Hematology and Oncology Unit, Pediatric Department, between August 2022 and September 2023.
Background: Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by abnormalities of T cells subsets. Programmed death-1 (PD-1) is a co-signaling inhibitory molecule in T cells that is involved in many autoimmune diseases.
Purpose: Here we aimed to measure changes in PD-1 expression and serum interferon-γ (IFN-γ) levels before and 1 month after treatment in pediatric patients with newly diagnosed ITP.
Article Synopsis
- Patients with hemophilia A show diverse bleeding patterns that don't consistently match their factor VIII deficiency levels.
- A study analyzed the levels of Plasminogen Activator Inhibitor 1 (PAI1) and Thrombin Activatable Fibrinolysis Inhibitor (TAFI) in hemophilia A patients compared to healthy controls, using the ISTH/BAT tool to assess bleeding tendencies.
- Results indicated that while hemophilic patients had higher bleeding scores and differing PAI1 and TAFI levels compared to controls, only PAI1 showed a significant correlation with bleeding severity, suggesting it may be a predictor of bleeding risk in these patients.
Objective/background: To assess the percentage of CD4, CD8, and natural killer cells (CD16, CD56) in children with immune thrombocytopenic purpura (ITP) at presentation and study their impact on disease chronicity.
Methods: This case-control study was conducted at the Pediatric Hematology and Oncology Unit, Menoufia University Hospital (tertiary care center in Egypt). The study was held on 30 children presenting with ITP; they were followed-up and classified into two groups: 15 children with acute ITP; and 15 children with chronic ITP.
Article Synopsis
- The study aimed to evaluate bone mineral density (BMD) in children with idiopathic nephrotic syndrome (NS) who have normal kidney function.
- Children with NS (both steroid-sensitive and steroid-resistant) were compared to healthy controls for differences in BMD and mineral levels.
- Results showed lower calcium and higher phosphorus, parathyroid hormone, and alkaline phosphatase levels in children with NS, with notable instances of osteopenia and osteoporosis linked to steroid treatment.