Design, spectroscopic characterizations, and biological investigation of oxospiro[chromine-4,3-indolene]-based compounds as promising antiproliferative EGFR inhibitors and antimicrobial agents.

Utilizing microwave heating and an aqueous saturated solution of KCO as a catalyst, a rapidone-pot synthesis of oxospiro[chromene-4.3-indoline] derivatives was produced in high yields. The experimental results confirmed that the saturated solution of KCO gives outstanding yield to dangerous metals and strong bases during investigations into high-performance catalysts.

Thieno[2,3-]thiophene Derivatives as Potential EGFR and EGFRT Inhibitors with Antioxidant Activities: Microwave-Assisted Synthesis and Quantitative In Vitro and In Silico Studies.

Microwave-assisted synthesis and spectral analysis of certain novel derivatives of 3,4-diaminothieno[2,3-]thiophene-2,5-dicarbonitrile were carried out. Compounds were examined for cytotoxicity against MCF-7 and A549 cell lines using the quantitative MTT method, and gefitinib and erlotinib were used as reference standards. Compounds were shown to be more active than erlotinib against the two cell lines tested.

Efficient and Recoverable Bio-Organic Catalyst Cysteine for Synthesis, Docking Study, and Antifungal Activity of New Bio-Active 3,4-Dihydropyrimidin-2(1)-ones/thiones Under Microwave Irradiation.

An eco-friendly green bio-organic catalyst and low-cost 3,4-dihydropyrimidin-2(1)-ones/thione derivatives have been synthesized using a high-yield, synthetic method a one-pot, three-component process between 4-formylphenyl-4-methylbenzenesulfonate (), thiourea, or urea and ethyl acetoacetate or acetylacetone under microwave irradiation in aqueous media of water and ethanol (3:1 ratio) as a green solvent in the presence of cysteine as a new green bio-organic catalyst. The reaction between compound , 4-(carbamothioylhydrazono) methyl]phenyl 4-methyl benzenesulfonate (), and ethyl acetoacetate or acetylacetone under the same condition afforded novel pyrimidines. Similarly, compound was allowed to react with a mixture of 4-(carbamothioylhydrazono)methyl]phenyl 4-methyl benzenesulfonate () and ethyl acetoacetate or acetylacetone under the same condition to afford pyrimidine derivatives and .

Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3-] Pyrrole Derivatives.

Novel pyrrolo [2,3-] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chemical structures of the new derivatives were confirmed through spectral analysis. Compounds and were revealed to be the most effective hypolipidemic agents, with considerable hypocholesterolemic and hypotriglyceridemic effects.

Synthesis and Toxicological Effect of Some New Pyrrole Derivatives as Prospective Insecticidal Agents against the Cotton Leafworm, (Boisduval).

Herein, a series of biologically active pyrrole derivatives, namely 2-[(3-cyano-5-aryl-1-pyrrol-2-yl)thio]acetic acids , 2-[(2-hydroxyethyl)-thio]-5-aryl-1-pyrrole-3-carbonitriles , and 2-[(2-amino-ethyl)thio]-5-aryl-1-pyrrole-3-carbonitriles , 2,2'-disulfanediylbis(5-aryl-1-pyrrole-3-carbonitriles) , 2-((3-cyano-5-aryl-1-pyrrol-2-yl)thio)acetates , 2-[(3-cyano-5-phenyl-1-pyrrol-2-yl)thio]acetohydrazides , and 2-{2-[(3-cyano-5-aryl-1-pyrrol-2-yl)thio]acetyl}--phenyl-hydrazinecarbothioamides , as insecticidal agents, were synthesized via adaptable, smoothly accessible 2-(2-oxo-2-arylylethyl)malononitriles . The structures were proved using infrared (IR), nuclear magnetic resonance (NMR), and mass spectrum (MS) techniques. Under laboratory conditions, the toxicological characteristics were tested towards , cotton leafworm insect type.

Development of New Thiazole Complexes as Powerful Catalysts for Synthesis of Pyrazole-4-Carbonitrile Derivatives under Ultrasonic Irradiation Condition Supported by DFT Studies.

In this study, we are interested in preparing Fe(III), Pd(II), and Cu(II) complexes from new thiazole derivatives. All syntheses were elaborately elucidated to estimate their molecular and structural formulae, which agreed with those of mononuclear complexes. The square-planer geometry of Pd(II) complex (MATYPd) was the starting point for its use as a heterocatalyst in preparing pyrazole-4-carbonitrile derivatives using ultrasonic irradiation through a facile one-pot reaction.

Unveiling the exceptional synergism-induced design of Co-Mg-Al layered triple hydroxides (LTHs) for boosting catalytic activity toward the green synthesis of indol-3-yl derivatives under mild conditions.

The current study provides a novel insight into the role of synergism of the changes in Mg/ Al in the best catalytic activity of indol-3-yl derivatives. A series of Co-Mg-Al layered triple hydroxides (LTHs) catalysts were produced by altering the Al/Mg ratio with respect to Co. The physicochemical properties of LTHs were well characterized by ICP-AES, XRD, FTIR, FE-SEM, BET, Zeta-sizer, and VSM.

Green Method for the Synthetic Ugi Reaction by Twin Screw Extrusion without a Solvent and Catalyst.

This study describes the solvent and catalyst-free Ugi reaction by way of twin screw extrusion (TSE). Multicomponent chemical synthesis can be converted into a single process without repeated use of solvents through TSE. High synthetic yields are achieved in short reaction times and produced in solvent-free conditions, which lead to a more environmentally friendly process.