New sesquiterpenes from the soft coral Litophyton arboreum.

Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon (2), and 5-epi-7α-hydroxy-( +)-oplopanone (3), were isolated from the soft coral Litophyton arboreum, together with nine known ones, including five sesquiterpenes; 11-hydroxy-8-oxo-β-cyperon (1), alismoxide (4), 5β,8β-epidioxy-11-hydroxy-6-eudesmene (5), chabrolidione B (6), 7-oxo-tri-nor-eudesm-5-en-4β-ol (7), two sterols; 7β-acetoxy-24-methyl-cholesta-5,24(28)-diene-3β,19-diol (8), nebrosteroid M (9), and two glycerol derivatives; chimyl alcohol (10) and batyl alcohol (11). The structures of the isolated compounds were characterized using spectroscopic techniques, predominately HR-ESI-MS, 1D, 2D-NMR, and ECD analyses. Compounds 1-11 were evaluated for their cytotoxic activity against three human cancer-cell lines (A549, MCF-7 and HepG2), and anti-leishmanial potential against the causal parasite, Leishmania major.

Aureanin: a new iridoid from the leaves of (Silva Manso) Benth. & Hook.f. ex S.Moore.

One new iridoid named aureanin () was isolated from the leaves of (Silva Manso) Benth. & Hook.f.

Cytotoxic and antileishmanial triterpenes of (Silva Manso) leaves.

The bioactivity-guided fractionation of the total ethanolic extract of the leaves of revealed the cytotoxic and antileishmanial potency of the ethyl acetate fraction, in which its phytochemical investigation resulted in the isolation of five triterpenes; identified as oleanolic acid (), ursolic acid (), pomolic acid (), tormentic acid (), 3,6,19-trihydroxy-urs-12-en-28-oic acid () in addition to one triterpenoid glucoside, spathodic acid 28---D-glucopyranoside (). Whereas compound showed cytotoxic activity against three different cell lines; A549, MCF-7 and HepG2 with IC values of 31.7 ± 1.

Cytotoxicity and chemical profiling of the Red Sea soft corals .

The objective of this research was to evaluate the cytotoxic activities of the fractions and isolated compounds of the soft corals against A549, MCF-7 and HepG2 cell lines by MTT assay method, and to chemically investigate the various metabolites of its total extract using LC-HR-ESI-MS metabolomic profiling. The metabolomic profiling revealed the presence of various metabolites, mainly sesquiterpenes and steroids reported for the first time in Additionally, eight compounds (-) have been isolated from the -hexane-chloroform (1:1) fraction that exhibited noticeable activity towards A549, MCF-7 and HepG2 cell lines. The steroids ( and ), and the sesquiterpene () exerted noticeable activity against A549 cell line (IC 28.

Gas chromatography-mass spectrometry profiling and analgesic, anti-inflammatory, antipyretic, and antihyperglycemic potentials of .

Objectives: The present study determines the chemical constituents of using gas chromatography-mass spectrometry (GC-MS) and its different activities.

Materials And Methods: Air-dried powdered leaves of were extracted by 95% methanol and fractionated consecutively with petroleum ether, chloroform, and ethyl acetate. The saponifiable matter, EtOAc and aqueous fractions were subjected to GC-MS.

Three species of Echinococcus granulosus sensu lato infect camels on the Arabian Peninsula.

We report on the genetic identity of 36 Echinococcus cysts that were collected during a recent slaughterhouse survey of 810 locally bred camels (dromedaries) in the Eastern Province of the Kingdom of Saudi Arabia. Analysis of a partial nad1 gene sequence showed that the majority (n = 29) belonged to E. granulosus sensu stricto, four to E.