Publications by authors named "Mahmoud A Elmeligy"
The application of smart pH-sensitive carriers has become an ideal choice for administering drugs with desired release profiles. Although pH-sensitive microbeads offer distinct benefits for delivering anticancer drugs orally, they encounter drawbacks, including low encapsulation efficiency, weak mechanical stability, biocompatibility concerns, and the risk of abrupt release. This study focuses on developing pH-sensitive coated composite microbeads for effective encapsulation and sustained release of 5-fluorouracil (5-FU).
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- Recent advancements in nanotechnology for nanomedicine show promise for enhancing cancer treatment through the use of innovative nanocomposite materials.
- Metallic nanoparticles improve the delivery and release of anticancer drugs, reducing necessary dosages and minimizing harm to healthy cells.
- Chitosan nanocomposites, especially when combined with gold and silver nanoparticles, offer improved stability and drug delivery capabilities, making them effective for targeting various anticancer drugs and enhancing therapeutic outcomes.
The present study aimed at preparing novel free-radical scavenging and water-soluble compounds derived from gelatin. Specifically, gelatin−syringaldehyde, gelatin−anisaldehyde, and gelatin−vanillin were synthesized and thoroughly studied for their physicochemical properties. In particular, the compounds were characterized by UV-Vis spectroscopy, Fourier-transform infrared spectroscopy, and scanning electron microscopy.
View Article and Find Full Text PDFBackground: Pericardial patches are often used for repair of congenital cardiac defects. The aim of this study was to describe our initial experience with the use of equine pericardium and its safety and advantages and disadvantages compared to bovine pericardium.
Methods: We designed a retrospective cohort study of 111 patients who were surgically treated for congenital heart disease between 2017 and 2020.