Rheum palmatum root extract inhibits hepatocellular carcinoma in rats treated with diethylnitrosamine.

Objectives: The aim of this study was to investigate the potential anticancer properties of a methanol extract of Rheum palmatum roots against diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC) in rats and to characterize its phytoconstituents.

Methods: HPLC-PDA-MS/MS was used to profile the secondary metabolites in R. palmatum root extract.