Characterization of bleeding in thrombotic thrombocytopenic purpura in the precaplacizumab era: a retrospective nationwide analysis.

Background: The addition of caplacizumab to immune thrombotic thrombocytopenia (iTTP) treatment options has led to a renewed interest in characterizing the epidemiology and risk factors for bleeding in iTTP. Limited data exist on the bleeding risk in iTTP due to systemic underreporting in earlier cohorts.

Objectives: To describe the incidence, patterns, and predictors of bleeding in hospitalized iTTP patients independent of caplacizumab use.

Predicting Water Saturation in a Greek Oilfield with the Power of Artificial Neural Networks.

Water saturation plays a vital role in calculating the volume of hydrocarbon in reservoirs and defining the net pay. It is also essential for designing the well completion. Innacurate water saturation calculation can lead to poor decision-making, significantly affecting the reservoir's development and production, potentially resulting in reduced hydrocarbon oil recovery.

The impact of retraction cords on the gingival margin level: A randomized clinical trial.

Purpose: To examine the impact of placing plain and impregnated retraction cords for two different retraction times on the postoperative gingival margin level and periodontal health.

Materials And Methods: A total of 40 endodontically treated mandibular first molars were selected and randomly allocated into four groups (n = 10/group); A: plain retraction cord for 10 min, B: plain retraction cord, 20 min, C: impregnated (25% aluminum chloride (AlCl) retraction cord, 10 min, D: impregnated retraction cord (25% AlCl), 20 min. Intraoral digital scans were acquired, and periodontal parameters (Plaque index [PI], Bleeding on probing [BOP], and probing depth [PD]) were assessed at baseline, 7 days, and 28 days after retraction.

Effect of Nutrition in the First Two Years of Life on Body Composition of Preschool-Aged Children.

Background Feeding and growth during infancy have been associated with later life body mass index and early excessive weight gain is associated with obesity later on. This study aimed to assess the effect of feeding in the first two years of life on the body composition of children at the preschool age and detect the importance of using bioelectrical impedance (BIA) analysis in identifying individuals at risk of overweight and obesity. Methods A cross-sectional study included 160 children.

Dexmedetomidine versus ketamine in improving tolerance to noninvasive ventilation after blunt chest trauma: A randomized, double-blinded, placebo-controlled trial.

Background And Aims: Even though patient tolerance is critical to the success of noninvasive ventilation (NIV), research on using sedation to improve tolerance to NIV after traumatic chest injuries is limited. We hypothesized that dexmedetomidine would be superior to ketamine in terms of patient tolerance and lengthening the NIV sessions after blunt chest trauma.

Material And Methods: This randomized, double-blinded, placebo-controlled trial included 45 patients of both genders aged 18-60 who needed NIV after blunt chest trauma.

Thyroid disorders in patients with human immunodeficiency virus infection: a meta-analysis.

Background: Thyroid disorders have significant clinical sequelae, including impaired growth in children, metabolic abnormalities, and impaired cognitive function. However, available studies on burden of thyroid diseases in people with human immunodeficiency virus (HIV), particularly its prevalence and its interaction with HIV related factors (like CD4 count), are controversial. This review aimed to provide a comprehensive summary and analysis on the extent of thyroid dysfunctions in this population.

Predicting the Rate of Penetration while Horizontal Drilling through Unconventional Reservoirs Using Artificial Intelligence.

Estimating the rate of penetration (ROP) is one of most critical tasks for evaluating the efficiency and profitability of drilling operation, which will aim in decision-making related to well planning, time estimation, cost estimation, bit selection, operational troubles, and logistics in drilling operation. The rise in unconventional resource development underscores the need for accurate ROP prediction to optimize drilling operations in these valuable reserves. ROP prediction and optimization in unconventional hydrocarbon reservoirs are challenging due to the formations' heterogeneity, high strength, and brittleness.

Anacyclus pyrethrum enhances fertility in cadmium-intoxicated male rats by improving sperm functions.

Background: Environmental pollutants, particularly heavy metals, have been frequently connected to male infertility. Cadmium was previously shown to reduce male fertility by causing oxidative stress. Anacyclus pyrethrum is a well-known medicinal plant.

Advances in Loading Techniques and Quality by Design for Fused Deposition Modeling in Pharmaceutical Production: A Systematic Review.

Background/objectives: Three-dimensional printing technology has emerging interest in pharmaceutical manufacturing, offering new opportunities for personalized medicine and customized drug delivery systems. Fused deposition modeling (FDM) is highly regarded in the pharmaceutical industry because of its cost effectiveness, easy operation, and versatility in creating pharmaceutical dosage forms. This review investigates different methods of incorporating active pharmaceutical ingredients (APIs) into filament matrices for use in fused deposition modeling (FDM) 3D printing.

Evaluation of Myocarditis in Patients With Still Disease: Clinical Findings From the Multicenter International AIDA Network Still Disease Registry.

Objective: We aimed to (1) evaluate the cardiac involvement, with a focus on myocarditis, in patients with Still disease included in the multicenter Autoinflammatory Disease Alliance (AIDA) Network Still disease registry; and (2) assess the predictive factors for myocarditis by deriving a clinical risk patient profile for this severe manifestation.

Methods: A multicenter observational study was established, in which consecutive patients with Still disease in the AIDA Network Still disease registry were characterized by cardiac involvement. Cardiac involvement was defined according to the presence of pericarditis, tamponade, myocarditis, and/or aseptic endocarditis.

Enhancing the properties of high-density oil well cement with Qusaiba kaolinite.

High-density cement slurries used in oil well cementing often face challenges such as particle settling, poor rheological properties, permeability, and compressive strength degradation, which can compromise zonal isolation and well integrity. This study focuses on using kaolinite, a clay mineral, as an additive due to its potential to improve the performance of high-density cement by modifying key properties. Several concentrations of kaolinite were examined to evaluate their influence on several cement properties such as rheology, thickening time, permeability, porosity, and compressive strength.

The Impact of Race and Ethnicity in Microvascular Head and Neck Reconstruction Postoperative Outcomes: A Nationwide Data Analysis.

Background: Racial and ethnic disparities have been extensively reported across surgical specialties, highlighting existing healthcare inequities. Nevertheless, evidence is lacking regarding their influence on postoperative outcomes after head and neck reconstruction. This study aimed to evaluate the impact of race and ethnicity on postoperative complications in head and neck microvascular reconstruction.

Compressive strength of nano concrete materials under elevated temperatures using machine learning.

In this study, four Artificial intelligence (AI) - based machine learning models were developed to estimate the Residual compressive strength (RCS) value of concrete supported with nano additives of Nanocarbon tubes (NCTs) and Nano alumina (NAl), after exposure to elevated temperatures ranging from 200 to 800 degrees. These models were developed via adapting meta- heuristic models including the Water cycle algorithm (WCA), Genetic algorithm (GA), and classical AI models of Artificial neural networks (ANNs), Fuzzy logic models (FLM), in addition to the statistical method of Multiple linear regression (MLR). 156 post heating experimental results available as a literature data (represents four input parameters of temperature change, heat exposure duration, nanomaterial type, and replacement proportion) are used to achieve the study's objective.

Bleeding outcomes in critically ill patients on heparin with discordant aPTT and anti-Xa activity.

Activated partial thromboplastin time (aPTT) and unfractionated heparin (UFH) level via the anti-factor Xa activity assay (anti-Xa) are commonly used assays for UFH monitoring. While discordance between the two assays is common, its impact on critically ill patient outcomes is unclear. This study aimed to compare the incidence of major bleeding events among critically ill patients with discordant aPTT and anti-Xa activity while on UFH, to patients with no discordance.

Impact of a short-term pharmacy study abroad Program: student outcomes and program evaluation.

Objective: This study examined the impact of a short-term study abroad program, focusing on program evaluation, attendee satisfaction, and acquired knowledge and skills. A questionnaire survey was conducted covering various aspects including demographics, program evaluation, and feedback.

Results: Results indicated higher female participation due to gender imbalances in pharmacy students in Egypt, with senior students recognizing the value of international experience.

Iron Homeostasis-Related Parameters and Hepcidin/Ferritin Ratio: Emerging Sex-Specific Predictive Markers for Metabolic Syndrome.

Metabolic syndrome (MetS) is a worldwide public health challenge. Accumulating evidence implicates elevated serum ferritin and disruptions in iron metabolism as potential elements linked to an increased risk of MetS. This study investigates the relationship between iron homeostasis-including hepcidin levels, serum iron concentration, unsaturated iron-binding capacity (UIBC), and the hepcidin/ferritin (H/F) ratio-and MetS.

Sustainable algal biorefinery: A review on current perspective on technical maturity, supply infrastructure, business and industrial opportunities.

The environmental problems associated with the use of fossil fuels demand a transition to renewable sources for fuels and energy. A biorefinery approach has often been considered and microalgae as a feedstock has been pampered for its numerous possibilities to produce biofuels. Depending on the species and cultivation conditions, microalgae can produce fats, proteins and sugars.

Morin attenuates sepsis-induced acute kidney injury by regulating inflammatory responses, oxidative stress and tubular regeneration (morin and sepsis-induced acute kidney injury).

Sepsis-associated acute kidney injury (AKI) is a health complication, encompassing excessive inflammatory response, oxidative stress, and tubular necrosis; leading to kidney failure and death. Sepsis treatments are nonspecific and palliative. In this study, we evaluated the effect of morin, a flavonoid with known nephroprotective capabilities, on sepsis-induced AKI by dividing eighty male mice into: normal, morin-treated, septic, and septic mice treated with morin.

Investigation of the Electrokinetic Potential of Granules and Optimization of the Pelletization Method Using the Quality by Design Approach.

The preparation of pellets using a high-shear granulator in a rapid single-step is considered a good economic alternative to the extrusion spheronization process. As process parameters and material attributes greatly affect pellet qualities, successful process optimization plays a vital role in producing pellet dosage forms with the required critical quality attributes. This study was aimed at the development and optimization of the pelletization technique with the Pro-CepT granulator.

CELF4 (rs1786814) gene polymorphism and speckle-tracking Echocardiography for cardiovascular complications in childhood cancer survivors.

Background: Despite a well-known dose-dependent association between the risk of cardiac dysfunction and anthracycline, the risk of cardiac dysfunction for any given anthracycline dose varies between patients. So, we assessed CELF4 (rs1786814) gene polymorphism on anthracycline-related cardiotoxicity in childhood cancer survivors (CCS).

Methods: This comparative cross-sectional study included 53 CCS who had regular follow-up visits at the Pediatric Oncology Unit, Menoufia University Hospital.

The Impact of Metabolic Syndrome on Postoperative Outcomes in Abdominal Body Contouring: A Propensity Score-Matched Nationwide Analysis.

Background: Metabolic syndrome (MetS) represents cardiometabolic dysregulation, defined by hypertension, obesity, diabetes, and dyslipidemia. There remains a significant gap in our understanding of whether MetS impacts outcomes of abdominal body contouring procedures. We aimed to assess the influence of MetS on postoperative outcomes of abdominal body contouring by concurrent abdominoplasty and panniculectomy.

Representation of Racial Diversity on US Plastic Surgery Websites: A Cross-sectional Study: Racial Diversity on Plastic Surgery Websites.

Background: The racial diversity portrayed in plastic and reconstructive surgery (PRS) media is an important indicator of an inclusive environment for potential patients. To evaluate the degree to which PRS websites demonstrate inclusivity, we assessed the racial composition of both patients and plastic surgeons depicted on the most visited academic and private PRS websites to determine the extent to which racial diversity is represented.

Methods: A cross-sectional study was conducted in September 2023.