The increasing bacterial resistance and negative impacts of the present antibacterial agents have led to the search for novel antibacterial agents. This study focuses on the influence of synthetic methods on the aggregation stability and antibacterial activity of gold nanoparticles (NPs) prepared by using sodium citrate as a reducing and capping agent against (). Gold NPs were synthesized using a simple and rapid sonochemical method and compared to gold NPs synthesized using a reduction method.
View Article and Find Full Text PDFBackground: Gold nanoparticles (Au NPs) are regarded as potential agents that enhance the radiosensitivity of tumor cells for theranostic applications. To elucidate the biological mechanisms of radiation dose enhancement effects of Au NPs as well as DNA damage attributable to the inclusion of Au NPs, Monte Carlo (MC) simulations have been deployed in a number of studies.
Scope Of Review: This review paper concisely collates and reviews the information reported in the simulation research in terms of MC simulation of radiosensitization and dose enhancement effects caused by the inclusion of Au NPs in tumor cells, simulation mechanisms, benefits and limitations.
Photodiagnosis Photodyn Ther
June 2023
AuNPs-mediated photothermal therapy (PTT) is gaining popularity in both laboratory research and medical applications. It has proven clear advantages in breast cancer therapy over conventional thermal ablation because of its easily-tuned features of irradiation light with inside hyperthermia ability. Notwithstanding this significant progress, the therapeutic potential of AuNPs-mediated PTT in cancer treatments is still impeded by several challenges, including inherent non-specificity, low photothermal conversion effectiveness, and the limitation of excitation light tissue penetration.
View Article and Find Full Text PDFGold nanoparticles (AuNPs) are becoming increasingly popular as drug carriers due to their unique properties such as size tenability, multivalency, low toxicity and biocompatibility. AuNPs have physical features that distinguish them from bulk materials, small molecules and other nanoscale particles. Their unique combination of characteristics is just now being fully realized in various biomedical applications.
View Article and Find Full Text PDFUpconversion (UC) of lanthanide-doped nanostructure has the unique ability to convert low energy infrared (IR) light to high energy photons, which has significant potential for energy conversion applications. This review concisely discusses the basic concepts and fundamental theories of lanthanide nanostructures, synthesis techniques, and enhancement methods of upconversion for photovoltaic and for near-infrared (NIR) photodetector (PD) application. In addition, a few examples of lanthanide-doped nanostructures with improved performance were discussed, with particular emphasis on upconversion emission enhancement using coupling plasmon.
View Article and Find Full Text PDFCombining iron oxide nanoparticles (FeO NPs) and gold nanoparticles (Au NPs) in one nanostructure is a promising technique for various applications. FeO NPs have special supermagnetic attributes that allow them to be applied in different areas, and Au NPs stand out in biomaterials due to their oxidation resistance, chemical stability, and unique optical properties. Recent studies have generally defined the physicochemical properties of nanostructures without concentrating on a particular formation strategy.
View Article and Find Full Text PDFSonochemistry uses ultrasound to improve or modify chemical reactions. Sonochemistry occurs when the ultrasound causes chemical effects on the reaction system, such as the formation of free radicals, that intensify the reaction. Many studies have investigated the synthesis of nanomaterials by the sonochemical method, but there is still very limited information on the detailed characterization of these physicochemical and morphological nanoparticles.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
June 2021
The 2019 novel coronavirus (2019-nCoV; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) has witnessed a rapid and global proliferation since its early identification in patients with severe pneumonia in Wuhan, China. As of 27th May 2020, 2019-nCoV cases have risen to >5 million, with confirmed deaths of 350,000. However, Coronavirus disease (COVID-19) diagnostic and treatment measures are yet to be fully unraveled, given the novelty of this particular coronavirus.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
March 2021
The production of nanomaterials integrating diagnostic and therapeutic roles within one nanoplatform is important for medical applications. Such theranostics nanoplatforms could provide information on imaging, accurate diagnosis and, at the same time, could eradicate cancer cells. FeO@Au core@shell nanoparticles (FeO@AuNPs) have gained broad attention due to their unique innovations in magnetic resonance imaging (MRI) and photothermal therapy (PTT).
View Article and Find Full Text PDFA highly stable and magnetized citric acid (CA)-functionalized iron oxide aqueous colloidal solution (FeO@CA) was synthesized by using a simple and rapid method of one-step co-participation via a chemical reaction between Fe and Fe in a NaOH solution at 65 °C, followed by CA addition to functionalize the FeO surface in 25 min. The NPs were synthesized at lower temperatures and shortened time compared with conventional methods. Surface functionalization is highly suggested because bare FeO nanoparticles (FeO NPs) are frequently deficient due to their low stability and hydrophilicity.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
September 2020
Background: Theranostic agents can combine photosensitizers and contrast agents into a single unit for photothermal therapy (PTT) and magnetic resonance imaging (MRI). The possibility of treating and diagnosing malignant cancers without any ionizing radiation could become an option. This study investigates the theranostic potential of FeO nanoparticles (IONs) for the diagnosis and treatment of cancer by developing a single integrated nanoprobe.
View Article and Find Full Text PDFSonochemical synthesis (sonochemistry) is one of the most effective techniques of breaking down large clusters of nanoparticles (NPs) into smaller clusters or even individual NPs, which ensures their dispersibility (stability) in a solution over a long duration. This paper demonstrates the potential of sonochemistry becoming a valuable tool for the deposition of gold (Au) shell on iron oxide nanoparticles (FeO NPs) by explaining the underlying complex processes that control the deposition mechanism. This review summarizes the principles of the sonochemistry method and highlights the resulting phenomenon of acoustic cavitation and its associated physical, chemical and thermal effects.
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