Antibacterial action of quinolones on Escherichia coli. I. Structure/activity relationship.

Quinolones, a large group of substituted heterocyclic compounds synthesized by ICI (U.K.), showed antibacterial activity both in vivo and in vitro studies.

Antibacterial action of quinolones on Escherichia coli. IIa. Conditions required for lethality: effect of anaerobiosis, inoculum size and media composition.

Quinolones with carboxylic or nitroside groups behaved differently in vitro under various physiological conditions tested. CarboxyQ was not active during the lag phase of E. coli and its activity was proportional to the growth rate under anaerobic conditions.