Publications by authors named "Mahmood L"

Article Synopsis
  • The review examines how different diet quality scores relate to obesity and Metabolic Syndrome (MetS) in kids and teens.
  • Research indicates that better adherence to diet quality scores, like the Mediterranean diet, is linked to lower body mass index (BMI) and waist circumference (WC), especially in children under 12.
  • The findings from 73 selected studies suggest that a high-quality diet can help protect against obesity and MetS in youth, with boys showing stronger associations.
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Background: The occurrence of life-threatening events in hospitalized patients with tracheostomies are often preventable. Nurses have a vital role in providing consistent tracheostomy care to patients, thereby avoiding complications. This study was conducted to assess the knowledge of nurses in high dependency areas at a tertiary care hospital with regards to tracheostomy care, to train them and to assess the impact of a tracheostomy care teaching module.

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Article Synopsis
  • Neuro-ophthalmic disorders in Iraq have not been well-documented, leading to a study aimed at understanding their clinical and demographic characteristics among patients at a Baghdad clinic.
  • Conducted from March 2021 to November 2022, the study included 6440 patients, with 613 newly diagnosed cases; ischemic optic neuropathy emerged as the most common condition, affecting 17.61% of those diagnosed.
  • Other prevalent issues included sixth nerve palsy, with a notable 42.7% of cases linked to diabetes and 39.3% to hypertension, indicating a significant occurrence of neuro-ophthalmic diseases in the region.
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Purpose Of Review: Precision medicine in pediatric asthma involves identification of asthma phenotypes, genetic markers, biomarkers, and biologics that target specific pathways. This review includes a discussion of the efficacy of currently approved biologics for pediatric asthma and most recent advances in biomarker/phenotype identification and genetic associations that affect asthma care.

Recent Findings: Biologics targeting type-2 mediated pathways have shown success in the treatment of moderate to severe asthma in pediatric and adult patients.

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Simulation-based training is an acceptable method in medical sciences. The available simulators and the conduct of simulation require both simulators and infrastructural requirements. This narrative review highlights the potential of digital tools for team-based simulation exercises in low-resource settings.

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Background: In India, orderlies are unlicensed hospital assistants instructed to perform delegated tasks under supervision by a licensed health-care giver. They receive on-the-job training, unlike certified nursing assistants. In this study, we have integrated a simulation session in our hospital orderly training program to promote the safe transfer of patients using a low-fidelity mannequin.

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Background: Three percent of pregnancies are complicated by congenital anomalies. Prenatal integration of pediatric palliative care (PPC) may be hindered by non-standardized PPC referral processes. This quality improvement (QI) project aimed to improve prenatal PPC consultation using a diagnostic trigger list.

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Article Synopsis
  • A new physiologically based pharmacokinetic (PBPK) model for adeno-associated virus (AAV) therapy was created to improve drug development, based on studies in mice.
  • The study examined the distribution of AAV8 and AAV9 vectors and their encoded monoclonal antibody (mAb) over three weeks, revealing tissue-to-blood concentration ratios that varied significantly across different organs.
  • The developed PBPK model captures the pharmacokinetics of both the AAV vector and the mAb, highlighting liver, muscle, and heart as key contributors to mAb secretion, and it will aid in preclinical study design and the transition from animal studies to human trials.
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Background: The frequency of family meals has been suggested as a protective factor against obesity among children.

Objective: This study aimed to investigate the cross-sectional and longitudinal associations between family meals frequency and children's overweight/obesity in families at high risk of type 2 diabetes (T2D) across six European countries.

Methods: 989 parent-child dyads (52% girls and 72% mothers) were included.

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Objective: To examine the parental food consumption and diet quality and its associations with children's consumption in families at high risk for developing type 2 diabetes mellitus across Europe. Also, to compare food frequency consumption among parents and children from high-risk families to the European Dietary guidelines/recommendations.

Design: Cross-sectional study using Feel4diabetes FFQ.

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Background: Hematopoietic stem cell transplant (HSCT) is associated with significant morbidity and high symptom burden including mucositis pain, nausea, and vomiting. There is little documentation in the literature regarding acupuncture or acupressure for children undergoing HSCT.

Objective: The purpose of this study was to determine the safety and acceptance of acupuncture and acupressure in children undergoing HSCT in a large tertiary care children's hospital.

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Objective: This study aimed to investigate the mediating role of food parenting practices (FPP), including home availability of different types of foods and drinks, parental modelling of fruit intake, permissiveness and the use of food as a reward in the relationship between parental education and dietary intake in European children.

Design: Single mediation analyses were conducted to explore whether FPP explain associations between parents' educational level and children's dietary intake measured by a parent-reported FFQ.

Setting: Six European countries.

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Article Synopsis
  • Family meals, defined as meals shared with family members or at least one parent present, are linked to healthier eating habits for both parents and children, especially in families at high risk for type 2 diabetes in Europe.
  • The study found that more frequent family meals correlate with better food consumption and diet quality among parents (β = 0.84) and healthier eating patterns in children, with significant associations for both boys and girls.
  • Parental diet quality partially mediates the relationship between family meal frequency and children's food consumption, particularly impacting specific food items like milk products and salty snacks, especially during family breakfasts for girls.
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Primary palliative care education and mentoring strengthens frontline clinicians' confidence and competence in pediatric palliative care, and potentially mitigates their moral distress. The project aims were to improve the knowledge, attitudes, and skills of frontline intradisciplinary clinicians in caring for children with serious conditions and their families. We undertook an intensive educational initiative consisting of didactic and mentoring sessions, and mentored quality improvement projects.

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Context: Acute episodes of pain associated with sickle cell disease (SCD) account for over 100,000 hospitalizations and expenses of nearly one billion dollars annually in the U.S. New treatment approaches are needed as the current opioid based therapy is often inadequate in controlling pain, resulting in prolonged inpatient stays, and high rates of readmission.

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Poor dietary habits established during childhood might persist into adulthood, increasing the risk of developing obesity and obesity-related complications such as Type 2 Diabetes Mellitus. It has been found that early modifications in eating habits, especially during childhood, might promote health and decrease the risk of developing diseases during later life. Various studies found a great influence of parental dietary habits on dietary behaviors of their children regardless of demographic characteristics such as gender, age, socioeconomic status and country; however, the exact mechanism is still not clear.

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Background: Learning in silos during the undergraduate years results in ineffective collaborative practice leading to adverse events. Simulation training using the Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS)® framework has been shown to be effective in enhancing teamwork skills among healthcare professionals. This study aims to evaluate an interprofessional simulation education (IPSE) module for undergraduate medical and nursing students on teamwork and communication skills using the TeamSTEPPS® framework.

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Context: Painful vaso-occlusive crises (VOCs) associated with sickle cell disease (SCD) are the most common cause of morbidity, hospitalizations, and poor quality of life. Additional symptoms such as sleep disturbances, fatigue, and stress are also common. Non-traditional approaches are often used by families, but concerns remain that patients may forgo standard of care effective therapies in favor of dangerous unproven alternatives.

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Pain associated with sickle cell disease (SCD) is frequently treated with opioids which have many side effects. There is a need for adjuvant non-opioid therapies that can improve pain control. Acupuncture, an integrative approach, has been shown to be useful in non-SCD pain conditions but has been used to a very limited extent in SCD.

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Two of the leading strategies to prevent cervical cancer are prophylactic human papillomavirus (HPV) vaccination and routine Papanicolaou (Pap) testing. However, regardless of being vaccinated with first-generation (bivalent and quadrivalent) HPV vaccines at the recommended dosing schedule, many women are still found to have low- and high-grade cervical intraepithelial lesions. Studies have shown that this is largely due to: (1) first-generation vaccines only protecting against 70% of high-risk HPV types that cause cervical cancer (HPVs 16/18) and (2) vaccinated women being more prone to infection with non-protected high-risk HPV types than unvaccinated women.

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Background And Aims: Anaesthesia practice demands medical knowledge and skills as essential components for patient management in peri-operative emergencies. Since all residents are not exposed to such situations during their residency, training them using simulation technology could bridge this knowledge and skill gap. The aim of this study was to train and evaluate residents to manage anaesthesia emergencies on high fidelity simulators.

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