Synthesis of Acetaminophen-Based Coumarins as Selective COX-2 Inhibitors: An in vitro-in silico Study.

Acetaminophen, a centrally-acting old analgesic drug, is a weak inhibitor of cyclooxygenase (COX) isoforms with some selectivity toward COX-2. This compound was used in this work as a precursor to create nine acetaminophen based coumarins (ACFs). To satisfy the aim of this work, which states the synthesis of acetaminophen-based coumarins as selective COX-2 inhibitors, the ACFs were subjected to two types of investigation: in vitro and in silico.

Effects of Bee Propolis on FBG, HbA1c, and Insulin Resistance in Healthy Volunteers.

Objectives: Bee propolis is a natural substance that is used in traditional medicine due to its versatile pharmacological actions. This study evaluates whether short term use of bee propolis supplementation could have an impact on glycemic control in healthy individuals.

Materials And Methods: A single daily dose of 1000 mg of bee propolis was administered orally to a total of 34 healthy individuals for 60 days.

Anisotropic Strange Star in 5 Einstein-Gauss-Bonnet Gravity.

In this paper, we investigated a new anisotropic solution for the strange star model in the context of 5D Einstein-Gauss-Bonnet (EGB) gravity. For this purpose, we used a linear equation of state (EOS), in particular pr=βρ+γ, (where β and γ are constants) together with a well-behaved ansatz for gravitational potential, corresponding to a radial component of spacetime. In this way, we found the other gravitational potential as well as main thermodynamical variables, such as pressures (both radial and tangential) with energy density.

Vitamin D and Immunoglobulin E Status in Allergic Rhinitis Patients Compared to Healthy People.

Allergic rhinitis (AR) is a type of inflammatory condition that includes a group of symptoms, mainly affecting the nasal mucosa. Nasal obstruction, sneezing, stuffy or runny nose, in addition to swollen, itchy, red and watery eyes are the most common symptoms of the disease. These symptoms are triggered as a result of increased inflammatory mediators such as histamine and leukotrienes.

Cytotoxic and antimicrobial potential of different leaves extracts of used traditionally to treat diabetes.

Medicinal plant as herbal medicine is widely used to cure infectious diseases (s) has been studied for its antimicrobial and cytotoxic activities. Different polarity leave extracts were prepared by using hexane, chloroform, ethyl acetate and hydro alcoholic solvents. Agar diffusion method has been used to assess the antibacterial activity against two gram-positive and and two gram-negative and bacterial strains.

Designing Technology for Sociotechnical Problems: Challenges and Considerations.

Designing technology for sociotechnical problems is challenging due to the heterogeneity of stakeholders' needs, the diversity among their values and perspectives, and the disparity in their technical skills. Careful considerations are needed to ensure that data collection is inclusive and representative of the target populations. It is also important to employ data analysis methods that are compatible with users' technical skills and are capable of drawing a representative picture of people's values, priorities, and needs.

A Simple Low-Cost Wearable Sensor for Long-Term Ambulatory Monitoring of Knee Joint Kinematics.

Objective: Accurate monitoring of joint kinematics in individuals with neuromuscular and musculoskeletal disorders within ambulatory settings could provide important information about changes in disease status and the effectiveness of rehabilitation programs and/or pharmacological treatments. This paper introduces a reliable, power efficient, and low-cost wearable system designed for the long-term monitoring of joint kinematics in ambulatory settings.

Methods: Seventeen healthy subjects wore a retractable string sensor, fixed to two anchor points on the opposing segments of the knee joint, while walking at three different self-selected speeds.

Comparison of Antioxidant Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole.

Introduction: Peptic lesions usually develop when there is an imbalance between aggressive drivers and gastro-protective mediators that guard the lining of the gastrointestinal tract. The most crucial of these mediators are antioxidants, whose loss may predispose to oxidative stress, which is believed to be the main aggravator of several diseases including peptic ulcer. Proton pump inhibitors (PPIs) are drugs that are highly effective and widely used for therapeutic management of peptic disorders through inhibition of gastric acid secretion.

Reaction profiling of a set of acrylamide-based human tissue transglutaminase inhibitors.

The major function of the enzyme human tissue transglutaminase (TG2) is the crosslinking of proteins via a transamidation between the γ-carboxamide of a glutamine and the ε-amino group of a lysine. Overexpression of TG2 can lead to undesirable outcomes and has been linked to conditions such as fibrosis, celiac disease and neurodegenerative diseases. Accordingly, TG2 is a tempting drug target.