Anti-staphylococcal biofilm activity of miconazoctylium bromide.

We designed and synthesized miconazole analogues containing a substituted imidazolium moiety. The structural modification of the miconazole led to a compound with high potency to prevent the formation and disrupt bacterial biofilms, as a result of accumulation in the biofilm matrix, permeabilization of the bacterial membrane and generation of reactive oxygen species in the cytoplasm.

Diffusion of ions in a calcium alginate hydrogel-structure is the primary factor controlling diffusion.

The diffusion of solutes has been evaluated in an alginate hydrogel as a function of its structure. The role of solute and gel charge on the diffusion measurements were of particular interest. Diffusion coefficients were measured using fluorescence correlation spectroscopy as a function of solute charge and size, bulk solution ionic strength and pH, and gel density.

Diffusion and partitioning of cations in an agarose hydrogel.

Self- and mutual diffusion were measured in a low-melt 1.5% agarose hydrogel as a function of ionic strength (0.1-100 mM) and pH (3-7) for Cd(2+) and a charged rhodamine derivative.