Publications by authors named "Mahit Gupta"
Nuclear factor erythroid 2 like (Nfe2l) gene family members 1-3 mediate cellular response to oxidative stress, including in the central nervous system (CNS). However, neuronal functions of Nfe2l3 are unknown. Here, we comparatively evaluated expression of Nfe2l1, Nfe2l2, and Nfe2l3 in singe cell RNA-seq (scRNA-seq)-profiled cortical and retinal ganglion cell (RGC) CNS projection neurons, investigated whether Nfe2l3 regulates neuroprotection and axon regeneration after CNS injury in vivo, and characterized a gene network associated with Nfe2l3 in neurons.
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- Crmps (Collapsin response mediator proteins) are important for the growth and development of neurons, but their exact roles in the regeneration of injured CNS axons are not well understood, particularly for specific types: Crmp1, Crmp4, and Crmp5.
- In a study focusing on retinal ganglion cells (RGCs), researchers found that while all Crmp genes decreased during RGC maturation, Crmp4 was particularly effective at promoting axon regeneration following optic nerve injuries, and it also helps with RGC survival.
- The study revealed that the ability of Crmp proteins to support axon regeneration relates to neurodevelopmental processes that influence the intrinsic growth capabilities of RGCs.