Gabapentinoids: pharmacokinetics, pharmacodynamics and considerations for clinical practice.

The gabapentinoids are often recommended as first-line treatments for the management of neuropathic pain. The differing pharmacodynamic and pharmacokinetic profiles can have implications for clinical practice. This article has summarised these key differences.

Microbiological Evaluation of the Extension Wire and Percutaneous Epidural Lead Anchor Site Following a "2-Stage Cut-Down" Spinal Cord Stimulator Procedure.

Objectives: There are concerns regarding bacterial colonization of the temporary extension leads and subsequent infection risk using the 2-stage cut-down approach in spinal cord stimulation (SCS). We sought to quantify the extent of bacterial colonization of the temporary extension wire and percutaneous epidural lead anchor site.

Materials And Methods: We conducted a cross-sectional observational study recruiting a pragmatic sample of 25 consecutive patients listed for a cut-down trial of SCS.

Prospective analysis of the trial period for spinal cord stimulation treatment for chronic pain.

Objective: To determine patient preferences regarding the duration of trial period.

Materials And Methods: Forty patients were given a trial of spinal cord stimulation. They were questioned daily if they would like to proceed to a permanent implant.