Publications by authors named "Maheshwara Reddy Nadiveedhi"
Article Synopsis
- Hypochlorous acid (HOCl) is important for fighting pathogens, but too much or too little can cause tissue damage and inflammation.
- The new HOClSense dyes use a chlorination-based mechanism to provide detailed visualization of HOCl levels in sub-cellular environments, offering both switch-on and switch-off detection with different emission colors.
- Researchers demonstrated HOClSense's effectiveness by mapping HOCl in cell structures like plasma membranes and lysosomes, revealing insights into HOCl production in diseases like Niemann-Pick.
Article Synopsis
- Chloride is essential for various cellular functions, and its levels are controlled by transporters and channels, but real-time imaging of ion flux in these channels at the single-cell level has been lacking.
- Researchers created CytoCl dyes, a new type of pH-independent, chloride-sensitive fluorophore that allows for real-time imaging of chloride levels in cells, showing rapid changes that traditional imaging can't detect.
- CytoCl dyes successfully enabled the first-ever real-time imaging of ion flux through chloride channels in unmodified cells and also have a customizable version for different applications, enhancing our understanding of ion dynamics and membrane protein function.
Disclosed herein is a novel and efficient synthesis of dapagliflozin and canagliflozin, the most advanced sodium glucose cotransporter 2 inhibitors (SGLT2 inhibitors), for the treatment of type 2 diabetes mellitus (T2DM). Per Ac-protected thioester was prepared by the treatment of per Ac d-gluconolactone with 1-dodecanethiol and PrMgCl without affecting labile Ac-protecting groups. Aryl bromide (ArBr) was synthesized through reduction of diaryl ketone to diaryl methane by the TiCl/NaBH/DME-MeOH reduction system.
View Article and Find Full Text PDFSynthesis of diarylmethanes, a key building block for SGLT2 inhibitors, has been developed through ketone synthesis by Friedel-Crafts acylation with TiCl, followed by reduction with TiCl/NaBH. The new protocol proceeded more cleanly than the previous methods employing AlCl and BF·OEt/EtSiH to provide the diarylmethanes corresponding to canagliflozin, empagliflozin, and luseogliflozin in a highly expedient and affordable manner. In the case of a diarylmethane for the synthesis of dapagliflozin, the reduction step took place by an alternative method using InCl/Al/BF·OEt.
View Article and Find Full Text PDFA series of novel α-furfuryl-2-alkylaminophosphonates have been efficiently synthesized from the one-pot three-component classical Kabachnik-Fields reaction in a green chemical approach by addition of an generated dialkylphosphite to Schiff's base of aldehydes and amines by using environmental and eco-friendly silica gel supported iodine as a catalyst by microwave irradiation. The advantage of this protocol is simplicity in experimental procedures and products were resulted in high isolated yields. The synthesized α-furfuryl-2-alkylaminophosphonates were screened to antioxidant and plant growth regulatory activities and some are found to be potent with antioxidant and plant growth regulatory activities.
View Article and Find Full Text PDF