Cortical Control of Spatial Resolution by VIP+ Interneurons.

Unlabelled: Neuronal tuning, defined by the degree of selectivity to a specific stimulus, is a hallmark of cortical computation. Understanding the role of GABAergic interneurons in shaping cortical tuning is now possible with the ability to manipulate interneuron classes selectively. Here, we show that interneurons expressing vasoactive intestinal polypeptide (VIP) regulate the spatial frequency (SF) tuning of pyramidal neurons in mouse visual cortex.