Publications by authors named "Mahesh M Pisal"
The diastereoselective formal synthesis of (-)-quinagolide, a D receptor agonist, has been achieved. The synthesis started from l-pyroglutamic acid and relied on utilization of (a) a stereospecific catalytic hydrogenation and diastereoselective Horner-Emmons-Michael cascade to obtain functionalized prolinate, (b) a Lewis acid mediated Pummerer cyclization to construct a tricyclic fused ring system, and (c) a diastereoselective ring expansion via a bicyclic aziridinium intermediate to access the required 3-substituted piperidine scaffold.
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- A series of hybrid molecules featuring thienopyrimidinones and thiouracil were created and tested for their effectiveness against Mycobacterium tuberculosis, with some compounds showing promising antitubercular activity against both dormant and active stages of the bacteria.
- Research identified structural modifications on one compound, leading to a new derivative that also demonstrated significant activity, suggesting the potential for further optimization.
- Additionally, cytotoxicity studies indicated these compounds were non-toxic, and docking studies showed that one compound effectively bound to mycobacterial pantothenate synthetase, laying groundwork for the development of new antimycobacterial agents.
Synthesis of 3,4,5-triheterocyclyl-2,6-dicyanoanilines, starting from heterocyclic aldehydes and 1,2-diheterocycle-substituted ethanones, is described. 2,6-Dicyanoanilines with one or two heterocyclic substituents have also been synthesized. It was found that some of these molecules have selective cell-staining properties useful for cell imaging applications.
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