Mechanistic insights into high permeation vesicle-mediated synergistic enhancement of transdermal drug permeation.

To design a nanocarrier platform for enhanced transdermal drug permeation. Gel-based high permeation vesicles (HPVs) were developed and their performance in terms of transdermal flux improvement, release and skin irritancy was assessed. The mechanistic insights of permeation enhancement were explored using confocal laser scanning microscopy, ATR-FTIR, DSC and P NMR.

Skin delivery of resveratrol encapsulated lipidic formulation for melanoma chemoprevention.

An unmet need for patient friendly products can be achieved with novel, biocompatible lipidic formulations which encapsulate and prolong release of medicaments. The aim of this study was to develop a commercially scalable resveratrol-loaded solid-lipid microparticulate (SLM) topical gel for melanoma chemoprevention. Preformulation studies were conducted and drug-excipient interactions examined using infra-red spectroscopy and differential scanning calorimetry (DSC).

Solid lipid nanoparticles-loaded topical gel containing combination drugs: an approach to offset psoriasis.

Aim: The primary aim of present work was to develop effective combination drug therapy for topical treatment of psoriasis.

Methods: Betamethasone dipropionate and calcipotriol loaded solid lipid nanoparticles (CT-BD-SLNs) were prepared by hot melt high shear homogenization technique, which were then incorporated in Carbopol gel matrix. The anti-psoriatic potential was tested by sequential in vitro (skin permeation and dermal distribution, anti-proliferative effect in HaCaT cells) and in vivo (Draize patch irritation, transepidermal water loss (TEWL) and anti-psoriatic mouse tail studies) experiments.