Publications by authors named "Mahesh Gaikwad"
Development and characterization of formulations based on combinatorial potential of antivirals against genital herpes.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
Article Synopsis
- * The study developed immediate-release film and pessary formulations containing TDF and ZAD, which showed effective drug release within 1-90 minutes and were tested for their safety and antiviral effectiveness in the lab.
- * Results indicated that while ZAD had moderate antiviral activity, TDF was very effective, and their combination produced synergistic effects, suggesting these formulations could enhance treatment for HSV-2 with fewer systemic side effects, though further studies are needed before clinical use.
Background: Gold nanoparticles (GNP) have been used extensively in cancer biologics and as drug carrier systems for improved pharmacokinetics and effective therapeutic action. GNPs also ensure reliable diagnosis with sensitive imaging.
Objective: This study aimed to synthesize tizanidine hydrochloride (TZN)-biodegradable gold (Au) nanoparticles by the reduction of chloroauric acid (HAuCl4) with trisodium citrate using a microwave synthesizer and quality by design approach.
Host plant resistance mechanisms play an important role in developing cultivars with resistance to the target pests; information regarding morphological and biochemical factors contributing to the resistance is essential for developing pest-resistant cultivars. As a result, we investigated the contribution of various morphological and biochemical characters in forty-two eggplant genotypes against Leucinodes orbonalis Guenée, in Himachal Pradesh, India. Out of all the phenotypic parameters evaluated, pericarp thickness (r = 0.
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