Publications by authors named "Mahendrakumar C"
In the present communication, ZrTiO nanoparticles (NPs) are synthesized by the solution combustion method using urea (ZTOU) and oxalyl dihydrazide (ODH) (ZTODH) as fuel and calcined at 700 °C. The synthesized samples were characterized with different techniques. Powder X-ray diffraction studies show the presence of diffraction peaks corresponding to ZrTiO.
View Article and Find Full Text PDFIn the present study, we have evaluated the antitumor effects of vanadium by monitoring DNA damage and chromosomal aberrations (CAs) during the early preneoplastic stage of 1,2-dimethylhydrazine (1,2-DMH)-induced colon cancer in male rats. Treatment with 20 mg/kg 1,2-DMH for 6 weeks resulted in the formation of aberrant crypt foci (ACF), a putative preneoplastic lesion associated with colon cancer development, while cotreatment with ammonium monovanadate (0.5 ppm in the drinking water) reduced ACF formation by 50% (P < 0.
View Article and Find Full Text PDFVanadium (V) has recently been found to possess potent anti-neoplastic activity in rat colon carcinogenesis. In the present study attempts have been made to investigate the expression of the number and area of aberrant crypt foci positive for placental glutathione S-transferase (GST-P) during 1,2-dimethyl hydrazine (DMH)-induced rat colon carcinogenesis. Male Sprague Dawley rats were randomly divided into four groups.
View Article and Find Full Text PDFAim: To investigate the chemo preventive effects of vanadium on rat colorectal carcinogenesis induced by 1,2-dimethylhydrazine (DMH).
Methods: Male Sprague-Dawley Rats were randomly divided into four groups. Rats in Group A received saline vehicle alone for 16 weeks.