Association of HLA-Class II and IgE serum levels in pediatric asthma.

Background: Pediatric bronchial asthma is associated with considerable morbidity. The study was carried out to examine the association of Human Leukocyte Antigen (HLA)-Class II with the disease as we found no similar study on Asian Indian population.

Objective: To define the HLA-Class II antigens in Asian Indian pediatric patients with asthma.

Clinical profile, common thrombophilia markers and risk factors in 85 young Indian patients with arterial thrombosis.

Context And Objective: Arterial thrombosis may occur consequent to hereditary thrombophilia and increased lipoprotein(a) [Lp(a)] and fibrinogen. Our aim was to study the prevalence of common thrombophilia markers in 85 consecutive cases of arterial thrombosis.

Design And Setting: A retrospective study was conducted from 85 consecutive young patients treated as outpatients or admitted due to stroke or myocardial infarction at a tertiary care hospital.

Significance of panel reactive antibodies in patients requiring kidney transplantation.

Presence of antibodies against human leukocyte antigen (HLA) molecules, which may be may be directed against HLA class I or/and class II antigens, is a known risk factor for acute rejections and graft loss. Pre-transplantation panel reactive antibody (PRA) estimation is done to identify sensitized patients prior to solid organ transplantation and also forms the basis of cadaver organ allocation. The aim of this study is to evaluate the PRA in 52 patients awaiting first renal transplant, identify various factors contributing to high PRA, and observe its influence on graft survival.

Prevalence of common thrombophilia markers and risk factors in Indian patients with primary venous thrombosis.

Context And Objective: venous thrombosis occurs as a result of interaction of genetic and acquired factors including activated protein C resistance (APC-R), fibrinogen levels, antithrombin, protein C, protein S, lupus anticoagulants and anticardiolipin antibodies. This study was aimed at determining the prevalence of these common thrombophilia markers in Asian Indians with primary venous thrombosis.

Design And Setting: this was a cross-sectional study carried out in Mumbai.