Preparation and characterization of pectin/hydroxyethyl cellulose/clay/TiO bionanocomposite films for microbial pathogen removal from contaminated water.

Some of conventional wastewater disinfectants can have a harmful influence on the environment as well as human health. The aim of this investigation was synthesis and characterizes ecofriendly pectin/hydroxyethyl cellulose (HEC)/clay and pectin/HEC/clay incorporated with titanium dioxide nanoparticles (TiONPs) and use the prepared bionanocomposite as microbial disinfectants for real wastewater. Pectin/HEC/clay and pectin/HEC/clay/TiO bionanocomposite were characterized by various methods including X-ray diffraction (XRD), scanning electron microscope (SEM), and Fourier-transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA).

Alzheimer's disease progression detection based on optical fluence rate measurements using alternative laser wavelengths.

Alzheimer's disease (AD) levels have increased globally, which is considered the sixth reason for deaths. So, a requirement exists for economic and quantitative methods to follow up the gradual progression of AD. The current study presents a simulation for a non-irradiated, safe, wearable, and noninvasive mobile approach for detecting the progression of Alzheimer's brain atrophy using the optical diffusion technique and for investigating the difference between the normal and the diseased brain.

Safer spaces in youth development programs and health in Canadian youth.

Engagement in youth programs is a potential means to promote health and well-being across populations of young people. Safer spaces in these youth programs are likely critical in fostering positive health outcomes, but current research on the links between safer spaces and health is limited. In this exploratory study, we examined links between program safety in youth development programs and minoritized status, and health-related quality of life (HRQoL) and psychosomatic health complaints.

Social and self-stigma during COVID-19 pandemic: Egyptians' perspectives.

Background: Social stigma associated with infectious diseases existed throughout the history of pandemics due to fears of contagion and death. This study aims to assess social and self-stigma resulting from COVID-19 infection and other associated factors in Egypt during the pandemic.

Methods: A cross-sectional study was conducted on 533 adult Egyptians via an online questionnaire.

Influence of Tumor Volume on the Fluence Rate Within Human Breast Model Using Continuous-Wave Diffuse Optical Imaging: A Simulation Study.

This article investigates the effect of varying breast tumor size on the fluence rate distribution within a breast model during the diffuse optical imaging procedure. Early detection of breast cancer is of significant importance owing to its wide spread among women worldwide. Mastectomy surgery became very common due to the late detection of breast cancers by the conventional diagnostic methods such as X-ray mammography and magnetic resonance imaging.

Assessment of thyroid gland hormones and ultrasonographic abnormalities in medical staff occupationally exposed to ionizing radiation.

Background: Ionizing radiation (IR) is high-energy radiation that has the potential to displace electrons from atoms and break chemical bonds. It has the ability to introduce mutations, DNA strand breakage, and cell death. Being a radiosensitive organ, exposure of the thyroid gland to IR can lead to significant changes in its function.

Indicators of infertility and fertility care: a systematic scoping review.

Study Question: What is the scope of literature regarding infertility and fertility care indicators in terms of types and dimensions of these indicators?

Summary Answer: Most available infertility and fertility care indicators are outcomes indicators of effectiveness and efficiency dimensions.

What Is Known Already: The use of appropriate, relevant and valid indicators of infertility and fertility care is critical for monitoring access, equity and utilization.

Study Design Size Duration: A systematic scoping review was conducted.

Time-dependent biodistribution profiles and reaction of polyethylene glycol-coated iron oxide nanoclusters in the spleen after intravenous injection in the mice.

Polyethylene glycol (PEG) is widely used polymer in the field of pharmaceutics, particularly in which related to drug delivery systems (DDS). Surface coating of the nanoparticles (NPs) with PEG (i.e.

Numerical analysis of the optical fluence rate at the scalp for noninvasive brain tumor detection.

The present study provides a noninvasive, safe approach for brain tumor detection by numerically analyzing the optical fluence rate at the scalp. The proposed numerical investigation demonstrates the application of different laser wavelengths for identifying different types and volumes of brain tumors (glioma "grade II astrocytoma" and meningioma). The proposed method analyzes the spatial fluence rate distribution over the surface of the head after probing it with different infrared laser wavelengths (1000 and 1100 nm) to distinguish between normal and brain tumors.

A Review of Human Coronaviruses' Receptors: The Host-Cell Targets for the Crown Bearing Viruses.

A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-19 global pandemic.

A modified source-detector configuration for the discrimination between normal and diseased human breast based on the continuous-wave diffuse optical imaging approach: a simulation study.

Breast tumors are among the most common types of tumors that can affect both genders. It may spread to the whole breast without any symptoms. Therefore, the early detection and accurate diagnosis of breast tumors are significantly important.

17β-Estradiol activates Cl channels via the estrogen receptor α pathway in human thyroid cells.

Estradiol regulates thyroid function, and chloride channels are involved in the regulation of thyroid function. However, little is known about the role of chloride channels in the regulation of thyroid functions by estrogen. In this study, the effects of estrogen on chloride channel activities in human thyroid Nthy-ori3-1 cells were therefore investigated using the whole cell patch-clamp technique.

Risk Factors for Poor Outcome or Death in Young Children With Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infection: A Systematic Review and Meta-Analysis.

Background: Respiratory syncytial virus (RSV)-associated acute lower respiratory tract infection (RSV-ALRTI) constitutes a substantial disease burden in young children. We aimed to identify all studies investigating the risk factors for RSV-ALRTI poor outcome or death in young children.

Methods: We carried out a systematic literature review across 7 databases with data from studies published from January 1995 to December 2019.

Insights from ancient DNA analysis of Egyptian human mummies: clues to disease and kinship.

The molecular Egyptology field started in the mid-eighties with the first publication on the ancient DNA (aDNA) analysis of an Egyptian mummy. Egypt has been a major interest for historians, archeologists, laymen as well as scientists. The aDNA research on Egyptian biological remains has been fueled by their abundance and relatively well-preserved states through artificial mummification and by the advanced analytical techniques.

A systematic scoping review of COVID-19 during pregnancy and childbirth.

Background: Clinical presentation and outcomes of COVID-19 infection during pregnancy remain limited and fragmented.

Objectives: To summarize the existing literature on COVID-19 infection during pregnancy and childbirth, particularly concerning clinical presentation and outcomes.

Search Strategy: A systematic search of LitCovid, EBSCO MEDLINE, CENTRAL, CINAHL, Web of Science, and Scopus electronic databases.

A chloride channel in rat pancreatic acinar AR42J cells is sensitive to extracellular acidification and dependent on ROS.

Extracellular acidification, playing a promoting role in the process of acute pancreatitis, has been reported to activate Cl channels in several types of cells. However, whether extracellular acidification aggravates acute pancreatitis via activating Cl channels remains unclear. Here, we investigated the effects of extracellular acidification on Cl channels in rat pancreatic acinar AR42J cells using whole-cell patch-clamp recordings.

Characteristics of patients with systemic sclerosis living in Qatar.

The aim of this study was to determine the demographic, clinical, and immunological characteristics of patients with systemic sclerosis living in Qatar. This retrospective study included 42 patients with systemic sclerosis who attended Rheumatology Clinics at Hamad General Hospital in Doha, Qatar, between January 2000 and December 2014. All patients fulfilled the 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis.

Free-Wilson Analysis of Comprehensive Data on Phosphoinositide-3-kinase (PI3K) Inhibitors Reveals Importance of -Methylation for PI3Kδ Activity.

Phosphoinositide-3-kinase δ (PI3Kδ) is a critical regulator of cell growth and transformation and has been explored as a therapeutic target for a range of diseases. Through the exploration of the thienopyrimidine scaffold, we have identified a ligand-efficient methylation that leads to remarkable selectivity for PI3Kδ over the closely related isoforms. Interrogation through the Free-Wilson analysis highlights the innate selectivity the thienopyrimidine scaffold has for PI3Kδ and provides a predictive model for the activity against the PI3K isoforms.

Field evaluation of common poultry viral vaccinesin Egypt: a need for reassessment of the vaccine value chain.

Egypt has a large traditional and exotic poultry sector which is challenged regularly by poultry diseases in endemic and epidemic proportions. The household poultry in particular is a source of livelihoods and employment for millions of low income citizens. Highly pathogenic avian influenza (HPAI) H5N1 and Newcastle disease are the most important poultry diseases in this sector.

The Young Canadians Roundtable on Health: promising practices for youth and adults working in partnership.

Setting: Canadian youth (aged 15-29 years) are more diverse, educated, connected and socially engaged than ever before. However, many face health-related challenges, including mental health problems (10-20%), substance use concerns (14%) and obesity (45%).

Intervention: The Young Canadians Roundtable on Health (YCRH) was created in 2013 to be Canada's youth voice on health.

Development of a recombinant vaccine against foot and mouth disease utilizing mutant attenuated Listeria ivanovii strain as a live vector.

The drawbacks of conventional inactivated Foot and Mouth Disease (FMD) vaccine, such as escaping of the virus during manufacture processes prompted researchers to explore novel types of vaccine to overcome these disadvantages. Listeria ivanovii (LI) is an intracellular microorganism that possesses immune-stimulatory properties, making it appropriate for use as a live bacterial vaccine vector. The Foot and mouth disease virus (FMDV) VP1 protein is the most immunogenic part of FMDV capsid, it has most of the antigenic sites for viral neutralization.

Coating With Chitooligosaccharides Enhances the Cytokine Induction of Listeria ivanovii-Based Vaccine Strain.

Listeria ivanovi (LI) is an available live bacterial vaccine vector. This work attempted to coat LI-based vaccine candidates (LI-Rv0129c) with chitooligosaccharides (COSs) as an adjuvant to enhance the cellular immune responses induced. COS-bacteria composite was achieved by mixing the bacteria suspension with equal volume of COS solution, and this process accompanied with the increase of bacteria superficial zeta potential and formation of special superficial configurations.

Expression of the VP1 protein of FMDV integrated chromosomally with mutant Listeria monocytogenes strain induced both humoral and cellular immune responses.

Live vector-based vaccine is a modern approach to overcome the drawbacks of inactivated foot-and-mouth disease (FMD) vaccines such as improper inactivation during manufacture. Listeria monocytogenes (LM), an intracellular microorganism with immune-stimulatory properties, is appropriate to be utilized as a live bacterial vaccine vector. FMDV-VP1 protein has the capability to induce both cellular and humoral immune responses since it is considered the most immunogenic part of FMDV capsid and has the most of antigenic sites for viral neutralization.

Serum levels of chemerin, apelin, vaspin, and omentin-1 in obese type 2 diabetic Egyptian patients with coronary artery stenosis.

Cardiovascular diseases (CVD) are the leading cause of death in the diabetic population. Obesity is a serious problem that has been linked with CVD and diabetes via a variety of adipokines. The aims of this study were to evaluate and correlate circulating chemerin, apelin, vaspin, and omentin-1 levels in obese type 2 diabetic Egyptian patients with coronary artery stenosis (CAS), and to assess their usefulness as noninvasive diagnostic biomarkers.