Publications by authors named "Mahdieh Aliyari"
Cancer is recognized as one of the leading causes of death worldwide. In recent years, advancements in early detection and expanding treatment options have contributed to a decrease in mortality rates. However, the emergence of drug-resistant cancers necessitates the exploration of innovative and more effective drugs.
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- - The study evaluated the effect of N. sativa (black seed) on inflammation and oxidative stress in individuals with metabolic syndrome through a meta-analysis of 16 randomized controlled trials involving 1,033 participants.
- - Results indicated that N. sativa consumption significantly reduced several inflammatory markers (like CRP, TNF-α, IL-6) and MDA levels while increasing antioxidant levels (such as SOD and TAC).
- - In conclusion, the findings suggest that N. sativa may enhance oxidative stress and reduce inflammation in patients dealing with metabolic syndrome and related conditions.
Association Between Vitamin D Binding Protein Gene Polymorphism (rs7041), Vitamin D Receptor, and 25-Hydroxyvitamin D Serum Levels With Prostate Cancer in Kurdish Population in West of Iran.
Pathol Oncol Res
August 2022
Prostate cancer (PCa) pathology has been linked to vitamin D, vitamin D receptors (VDRs), and vitamin D binding proteins (VDBPs). We sought to investigate the association between VDR rs2228570 and rs1544410 as well as VDBP rs7041 polymorphisms and serum 25-hydroxyvitamin D (25(OH)-vitamin D) levels in PCa patients. Blood samples were collected from 111 PCa patients and 150 age-matched healthy volunteers.
View Article and Find Full Text PDFCaveolin-1(cav-1) is overexpressed in prostate cancer (PC) and is associated with progression of the disease. We investigated the effects of CAV1-T29107A and endothelial nitric oxide synthase (eNOS) G894T polymorphisms on the serum levels of testosterone, NO and prostate-specific antigen (PSA) in patients with PC. We genotyped cav-1 and eNOS genes in 112 PC patients and 150 healthy controls by PCR-RFLP.
View Article and Find Full Text PDFMatrix metalloproteinases (MMPs) are a group of zinc dependent enzymes that are involved in tumor cell invasion and metastasis. The role of MMP-2 and -9 genetic polymorphism in different malignancies has been the subject of numerous studies. The present research has attempted to discover any positive correlation between MMP-2 and MMP-9 SNPs and prostate cancer (PCa) in patients with a history of either diabetes or smoking habits.
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