Morphological Characterization and Genotyping of Isolates From Oral and Nasal Samples of Cancer Patients in Kashan, Iran.

species are recognized as the most prevalent free-living amoebae (FLA). They can cause granulomatous amebic encephalitis (GAE) and pulmonary and ocular infections. The present study aimed to isolate and identify genotypes in cancer patients referred to Kashan's hospitals in Central Iran.

Correction: Antileishmanial effect of podophyllotoxin and podophyllin on in vitro and in vivo.

[This corrects the article DOI: 10.1007/s12639-024-01654-6.].

Antileishmanial effect of podophyllotoxin and podophyllin on in vitro and in vivo.

Therapeutic research is very important in the prevention and treatment of leishmaniasis due to problems such as drug resistance, scarring and disease recurrence. The aim of this study was to determine how responds to the anti-leishmaniasis properties of podophyllotoxin and podophyllin. Cultured Leishmania promastigotes were exposed to different concentrations of podophyllotoxin and podophyllin for 24 and 48 h.

Molecular detection and genotype identification of species from bronchoalveolar lavage of patients with pulmonary symptoms suspected of cancer.

spp. are the most common free-living amoeba worldwide, inducing life-threatening diseases such as Granulomatous Amoebic Encephalitis, pulmonary infection, and amoebic keratitis. This study aimed to identify the FLA and genotypes in patients with pulmonary symptoms suspected of cancer in Kashan's hospitals, Kashan, Iran.

Scolicidal Effects of Chitosan-Curcumin Nanoparticles on the Hydatid Cyst Protoscolices.

Purpose: In the current era, cystic echinococcosis (CE), as larval stage of Echinococcus granulosus, is considered as a threat to human health. Scolicidal agents used in the surgery of cysts have different side effects. Therefore, the present study aimed to assess the effects of chitosan nanoparticles containing curcumin (Ch-Cu NPs) on the protoscolices of the hydatid cyst in vitro.

Giardia lamblia infection: review of current diagnostic strategies.

Giardiasis has a global distribution and it is a common cause of diarrhea in both children and adults and is transmitted via the fecal-oral route through direct or indirect ingestion of cysts. The laboratory diagnosis of Giardia spp. is mainly based on demonstration of microscopic cyst or trophozoite in stool samples but several immunological-based assays and molecular methods are also available for giardiasis diagnosis.

Epidemiology and economic loss of fasciolosis and dicrocoeliosis in Arak, Iran.

Aim: Fasciolosis and dicrocoeliosis are important parasitic diseases worldwide, causing significant financial losses due to decrease in production and viscera condemnation in animals. We performed the current research to assess the epidemiology of these infections and determine their significance from an economic perspective in Arak, Iran.

Materials And Methods: In total, we evaluated 118,463 sheep, 207,652 goats, and 43,675 cattle through necropsic analysis at the slaughterhouses.

Review of in Iran, Based on Epidemiological Situation.

Trichomoniasis, which is caused by , is the most common non-viral sexually transmitted infection (STI) in the world including Iran. There were roughly 250 million new cases all over the world in a year. as an important disease has been associated with HIV (in terms of exposure to sexually transmitted infection, STI) which increases the number of high-risk members, and thus it is an important public health problem.

Induction of Apoptosis by Alcoholic Extract of Combination and on Iranian Isolate of .

Background: The protozoan is a sexually transmitted disease (STD). Metronidazole is a chosen drug for the treatment. This study evaluated the anti trichomonal activity of alcoholic extracts of combination and

Methods: This experimental study was conducted in the Parasitology Laboratory, Kashan University of Medical Sciences, Kashan, Iran in 2015, on 23 women with suspected trichomoniasis referring to Kashan clinical centers.

Chitosan-titanium dioxide-glucantime nanoassemblies effects on promastigote and amastigote of Leishmania major.

The purpose of the present study was to design nanoassemblies of chitosan-titanium dioxide (TiO) nanoparticles (NPs) loaded with glucantime for using their synergistic effects and enhancing the toxic effects of glucantime on Leishmania parasites. The nanoassemblies were prepared by electrostatic interactions and optimized by a response surface central composite design. The effects of glucantime, chitosan and TiO NPs amounts were studied on the particle size, zeta potential, loading efficiency, and release efficiency of drug from nanoassemblies.

Molecular and Morphological Characterizations of from Human and Animal Isolates in Kashan, Markazi Province, Iran.

Background: One of the most important zoonotic helminths in the world is known as . Different strains of the have been described based on morphological and molecular characterizations, however, there is limited information regarding the characteristics of the phenotypes and genotypes of in Iran.

Methods: The present study was prepared to evaluate the phenotypic and genotypic diversity of isolates collected from human, goat, sheep, and cattle based on 19 standard morphometric parameters and mitochondrial and nuclear genes (, and ) in Kashan, Markazi Province, Iran during 2013-2014.

Genetic Variation of Isolates from Food-handlers in Kashan, Central Iran.

Background: Based on genotyping study of human isolates of ; humans are mainly infected by two assemblages A and B. The present study was carried out to determine the sub-assemblages of isolated from food handlers referred to Kashan health centers, central Iran, 2015.

Methods: In this cross-sectional study, 3653 stool samples collected from food-handlers that annually refer to health center for getting a health certification and examined microscopically for cyst.

Therapeutic effects of Iranian herbal extracts against Trichomonas vaginalis.

Trichomonas vaginalis is a flagellated parasite affecting about 276 million people annually worldwide. Tricomoniasis is associated with different complications in pregnant women and infants. 5'-nitroimidazole derivatives (metronidazole, ornidazole, and tinidazole) are FDA approved drugs recommended for trichomoniasis treatment.

Temporal Dynamics of Phlebotomine Sand Flies Population in Response to Ambient Temperature Variation, Bam, Kerman Province of Iran.

Background: Variations in climate condition may have changed the dynamic of zoonotic cutaneous leishmaniasis (ZCL) and its agents such as sand flies and reservoir in the Bam Kerman the dry region of Iran.

Objectives: In this study we intend to examine the seasonal and interannual dynamics of the phlebotomine mosquito as a function of ambient temperature in Bam, Kerman one of the main leshmaniasis prevalence area in Iran.

Methods: The MODIS land surface temperature product (LST; MODIS/Terra LST/E Monthly L3 Global 0.

Ginger (Zingiber officinale) induces apoptosis in Trichomonas vaginalis in vitro.

Background: Trichomoniasis is the most common sexually transmitted protozoan diseases in the worldwide. Metronidazole is the choice drug for trichomoniasis treatment, however, metronidazole resistant () has been reported. Natural products are the source of most new drugs, and (Ginger is widely used ingredient in the traditional medicine.

Spatiotemporal Anopheles Population Dynamics, Response to Climatic Conditions: The Case of Chabahar, South Baluchistan, Iran.

Background: An understanding of the factors that affect the abundance of Anopheline species provides an opportunity to better understand the dynamics of malaria transmission in different regions. Chabahar, located south east of Iran, is the most malarious region in the country.

Objective: The main aim of this study was to quantify the spatiotemporal Anopheles population dynamics, response to climatic conditions in Chabahar.

Tamoxifen Induces Apoptosis of Leishmania major Promastigotes in Vitro.

Tamoxifen is an antagonist of the estrogen receptor and currently used for the treatment of breast cancer. The current treatment of cutaneous leishmaniasis with pentavalent antimony compounds is not satisfactory. Therefore, in this study, due to its antileishmanial activity, effects of tamoxifen on the growth of promastigotes and amastigotes of Leishmania major Iranian strain were evaluated in vitro.

Molecular Diagnosis of Clinical Isolates of Cutaneous Leishmaniasis Using ITS1 and KDNA Genes and Genetic Polymorphism of Leishmania in Kashan, Iran.

Cutaneous leishmaniasis is a common skin disease caused by leishmania parasite. An accurate diagnosis of parasites species is possible using molecular techniques. This study was carried out to compare internal transcribed spacer (ITS1) and kinetoplast deoxyribonucleic acid (KDNA) genes for identifying Leishmania species by Polymerase Chain Reaction (PCR), furthermore, genetic diversity of isolates was studied.

Evaluation of Apoptotic and Antileishmanial Activities of Artemisinin on Promastigotes and BALB/C Mice Infected with Leishmania major.

Background: In leishmaniasis, some drugs prescribed for treatment have toxic effects and there are reports about drug resistance in some countries. Due to this fact, using herbal drugs such as artemisinin with good efficacy and low toxic effect might be suitable.

Methods: We evaluated the apoptotic effect of artemisinin on Leishmania major in vitro and the antileishmanial activities of artemisinin on leishmaniasis in BALB/c mice and at the end INF-γ and IL-4 cytokines levels were detected by ELISA in spleen cell culture supernatants.

Effect of Verbascum thapsus ethanol extract on induction of apoptosis in Trichomonas vaginalis in vitro.

Trichomoniasis is a sexually transmitted disease (STD) caused by a tiny parasite called Trichomonas vaginalis. Metronidazole is used as routine treatment of disease. Some reports have confirmed the potential carcinogenic and teratogenic effects of this drug on fetus and indication of drug resistance.

In vitro and in vivo antileishmanial effects of aloe-emodin on Leishmania major.

Cutaneous leishmaniasis is a common parasitic disease that is endemic in some parts of Iran. The drugs of choice used for leishmaniasis therapy are associated with a risk of recurrence and serious adverse effects. Therefore, finding a safe and effective treatment is of great importance.

Developing a climate-based risk map of fascioliasis outbreaks in Iran.

The strong relationship between climate and fascioliasis outbreaks enables the development of climate-based models to estimate the potential risk of fascioliasis outbreaks. This work aims to develop a climate-based risk map of fascioliasis outbreaks in Iran using Ollerenshaw's fascioliasis risk index incorporating geographical information system (GIS). Using this index, a risk map of fascioliasis outbreaks for the entire country was developed.

In Vitro Study on Cytotoxic Effects of ZnO Nanoparticles on Promastigote and Amastigote Forms of Leishmania major (MRHO/IR/75/ER).

Background: Although pentavalent antimony compounds are used as antileishmanial drugs but they are associated with limitations and several adverse complications. Therefore, always effort to find a new and effective treatment is desired. In this study, the effect of ZnO nanoparticles with mean particle size of 20 nanometers (nm) on Leishmania major promastigotes and amastigotes was evaluated.

Prevalence of Trichomonas vaginalis infection in Kashan city, Iran (2012-2013).

Background: Trichomonas vaginalis infection is one of the most common sexually transmitted diseases in humans. T.vaginalis is a parasitic protozoan with a predilection for human urogenital tract and causative agent for vaginitis, cervicitis and urethritis in females.