Publications by authors named "Mahbubeh Talaee"
Prior studies examined Acidocin 4356's antibacterial and antivirulence effects against Pseudomonas aeruginosa, including cell membrane penetration abilities. Building on prior research, an in-vitro co-culture of human cells was established to evaluate the selectivity of Acidocin (ACD) by concurrently cultivating human cells and bacterial pathogens. This study evaluated the antibacterial effectiveness of ACD against Acinetobacter baumannii and Pseudomonas aeruginosa.
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- The study focuses on improving the emulsifying ability of SA01-OmpA, a protein that previously faced issues like low production efficiency and high costs due to inclusion body formation.
- Researchers explored truncated forms of the protein to enhance its activity while reducing toxicity and the likelihood of forming inclusion bodies.
- The findings reveal that the N-terminally truncated SA01-OmpA variant significantly increases emulsifying activity and is less cytotoxic compared to the full-length protein, advancing both the understanding and application of this bioemulsifier.
Article Synopsis
- The outer membrane protein A (OmpA) from strain SA01 shows characteristics similar to its homologues, such as functioning as a slow porin, binding to peptidoglycan, and possessing emulsifying properties, highlighting its potential in biotechnology.* -
- SA01-OmpA can be secreted via outer membrane vesicles and is involved in biofilm formation, indicating its influence on the extracellular environment and microbial community structures.* -
- The expression level of OmpA is significantly influenced by oxidative stress from different carbon sources, suggesting that as oxidative stress increases, the production of OmpA also increases, representing a possible adaptive response in SA01.*