Britannin suppresses MCF-7 breast cancer cell growth by inducing apoptosis and inhibiting autophagy.

Objective: Breast cancer is the main reason for cancer-related death in women. Britannin is a sesquiterpene lactone compound derived from with anti-tumor properties. We aimed to explore the impacts of britannin on apoptosis and autophagy in MCF-7 breast cancer cell line.

Targeting of human fibroblast growth factor receptor 2 by a novel specific nanobody.

Inhibition of FGFR2 signaling is promising in targeted therapy of FGFR2-related tumors. In this study, anti-FGFR2 nanobodies (Nbs) were isolated through screening of an immune camelid phage display library. Four rounds of biopanning were carried out with commercial human FGFR2 antigen and enrichment was assessed by ELISA and phage titration.

Biological Activities and the Essential Oil Analysis of and .

This research aimed to evaluate the cytotoxicity, anti-bacterial, anti-fungal and heme polymerization inhibition activities, as well as the detection of the chemical composition of essential oils and measurement of the amount of total phenol and flavonoids of and . growth inhibitory effects of methanol extracts on A2780, T-47D, A549 and Hep-G2 cells were evaluated by MTT assay. MIC and MBC/MFC were determined by the agar dilution method.

Antimalarial Activities of ()-2-(Nitroheteroarylmethylene)-3(2)-Benzofuranone Derivatives: and Assessment and β-Hematin Formation Inhibition Activity.

A series of ()-2-(nitroheteroarylmethylene)-3(2)-benzofuranones possessing nitroheteroaryl groups of nitroimidazole, nitrofuran, and nitrothiophene moieties was screened for antiplasmodium activity against a drug-sensitive strain (3D7 strain) and a multidrug-resistant (chloroquine [CQ] and pyrimethamine) strain (K1 strain) of Plasmodium falciparum. 5-Nitroimidazole and 4-nitroimidazole analogs were highly selective and active against resistant parasites, while 5-nitrofuran and 5-nitrothiophene derivatives were more potent against the 3D7 strain than against the K1 strain. Among the synthetic analogues, ()-6-chloro-2-(1-methyl-5-nitroimidazol-2-ylmethylene)-3(2)-benzofuranone (compound 5h) exhibited the highest activity (50% inhibitory concentration [IC], 0.

Synthesis of novel amodiaquine analogs and evaluation of their and antimalarial activities.

Background & Objectives: Due to the rapid increase of drug resistance in Plasmodium parasites, there is a pressing need of developing new antiplasmodial drugs. In this study, new amodiaquine (AQ) analogs were synthesized, followed by an evaluation of their antiplasmodial activity.

Methods: A new series of quinoline derivatives containing N-alkyl (piperazin-1-yl)methyl benzamidine moiety was synthesized by reacting 4-[(4-(7-chloroquinolin-4-yl)piperazin-1-yl)methyl]benzonitrile with appropriate primary amines.

Leaves Antimicrobial Activity of Glycyrrhiza glabra L.

Licorice (Glycyrrhiza glabra L.) is an important medicinal plant. In this study, the antimicrobial activities of ethanolic and aqueous extracts from licorice leaves were studied compared to root extracts activities.